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Keywords

papillary cancer
thyroid gland
children and adolescents
Chernobyl disaster

How to Cite

Clinical and morphological features of papillary thyroid cancer in children and adolescents in the Republic of Belarus: analysis of 936 post-Chernobyl carcinomas. (2014). Voprosy Onkologii, 60(2), 43-46. https://doi.org/10.37469/0507-3758-2014-60-2-43-46

Abstract

There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid cancer in 936 children and adolescents. In general, carcinoma of these patients featured by locally advanced growth - 57.4% (387 of 674 patients with this sign could be assessed), metastases in regional lymph nodes - 73,7% (N1b in 40.7 %) and internal organs - 11.1%. The mean duration of follow-up was 12,4 ± 3,5 years (range 4.3 to 19.6 years) including children 14,6 ± 2,7 years (range 8.8 to 19.6 years) and adolescents - 10,1 ± 3,1 years (range 4.3 to 18.8 years). Overall survival for the 20-year period was 96,6% ± 1,2%. The causes of death were suicide (7), injuries and accidents (5), secondary malignancies (1), somatic diseases (2). Only in two patients the death was related to the main disease - lung metastases. Free-recurrence survival for the cohort of post-Chernobyl carcinomas was 92,7% ± 1,0%.
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References

Enomoto Y., Enomoto K., Uchino S. et al. Clinical features, treatment, and long-term outcome of papillary thyroid cancer in children and adolescents without radiation exposure // World J Surg. - 2012. - Vol. 36. - P. 1241-1246

Harness J.K., Thompson N.W., Nishiyama R.H. Childhood thyroid carcinoma // Arch Surg. - 1971. - Vol.102. - P. 278-284.

Hogan A.R., Zhuge Y., Perez E.A. et al. Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients // Journal of surgical research. - 2009. - Vol. 156. - P. 167-172.

LiVolsi V.A., Abrosimov A.A., Bogdanova T. et al. The Chernobyl thyroid cancer experience: pathology // Clinical Oncology. - 2011. - Vol. 23. - P. 261-267.

Nikiforov Yu.E. Molecular analysis of thyroid tumors // Modern Pathology. - 2011. - Vol. 24. - S. 34-43.

Pacini F., Vorontsova T., Demidchik E.P. et al. Post-Chernobyl thyroid carcinoma in Belarus children and adolescents: comparison with naturally occurring thyroid carcinoma in Italy and France // J of Clinical Endocrinology a. Metabolism. - 1997. - Vol. 82. №11. - P. 3563-3569.

Vaisman F., Corbo R., Vaisman M. Thyroid carcinoma in children and adolescents-systematic review of the literature // J. Thyroid Research. - 2011. -doi:10,4061/2011/845362.

Williams E.D. Radiation carcinogenesis: lessons from Chernobyl // Oncogene. - 2009. - Vol. 27. - P. 9-18.

Williams E.D., Abrosimov A., Bogdanova T. et al. Thyroid carcinoma after Chernobyl: latent period, morphology and aggressiveness // Br. J. Cancer. - 2004. - Vol. 90. - P. 2219-2224.

Williams E.D., Abrosimov A., Bogdanova T. et al. Morphological characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake // Thyroid. - 2008. - Vol. 18. - P. 847-852.

Zablotska L.B., Ron E., Rozhko A.V. et al. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chernobyl accident // British Journal of Cancer. - 2011. - Vol. 104. - P. 181 - 187.

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