Keywords
IGF-1
prostaglandin synthesizing cells
cells to histamine receptors
How to Cite
Abstract
Taking into account the information about the role of insulin-like growth factor -1 (IGF-1) in breast cancer the main aim of the present study was to investigate the cellular immune response to IGF- 1. There were examined 58 patients with breast cancer (61 ±1 years , ВМІ 31,2 ± 0,9 kg/m2 , all postmenopausal ) and 10 with benign tumors of the breast (56 ± 2 years , ВМІ 30,8 ± 0,7 kg/m2 all menopausal ) as well as 17 patients suffering from cancer of different sites. Sensibilization of lymphocytes to IGF-1 was measured in the reaction of blast transformation of peripheral blood lymphocytes. The majority of breast cancer patients (47/58) revealed the sensibilization of peripheral blood lymphocytes to IGF-1. Thus in a part of patients (29 /47) this reaction was suppressed and revealed after suppression of cyclooxygenase and/or blocking of the histamine H2-receptors by corresponding pharmaceutics drugs in vitro.References
Алехин Е.К., Лазарева Д.Н., Сибиряк С.В. Иммунотропные свойства лекарственных средств. Уфа, 1993.
Костылева О. И., Герштейн Е. С., Дигаева М. А. и др. Инсулиноподобные факторы роста, их рецепторы и связывающие белки как патогенетические факторы и потенциальные мишени терапии в онкологии // Вопр. биол., мед., фарм. химии. - 2009. - № 6. - С. 3-8.
Кушлинский Н.Е. Семинар по клинической маммологии. - М., Изд-во АБВ-Пресс. - 2006.
Allen N.E., Roddam A.W., Allen D.S. et al. A prospective study of serum insulin-like growth factor-1 (IGF-1), IGF-N, IGF-binding protein-3 and cancer risk // Br J Cancer. -2005. - Vol. 92. - P. 1283-1287.
Goodwin J.S., Bankhurst A.D., Messner R.P. Suppressian of human T-cell mitogenesis by prostaglandin // J Clin Med. - 1977. - Vol. 146. - P. 1719-1734.
Gunter M.J., Hoover D.R., Yu H. et al. Insulin, insulinlike growth factor-1 and risk of breast cancer in postmenopausal women // J Natl Cancer Inst. - 2009. - Vol. 101. - P. 48-60.
Shernhammer E.S., Holly J.M., Pollack M.H., Hankinson S.E. Circulating levels of insulin-like growth factors, their binding proteins and breast cancer risk // Cancer Epidemiol Biomarkers Prev. - 2005. - Vol. 14. - P. 699-704.
Smith G.D., Gunnell D., Holly J. Cancer and insulinlike growth factor-1. A potential mechanism linking environment with cancer risk // BMJ. - 2000. - Vol. 321. - P. 847.
Smith T.J. Insulin-like growth factor-1 regulation of immune function: a potential therapeutic target in autoimmune diseases? // Pharm Reviews. - 2010. - Vol. 62. - P. 199-236.
Tapson V.F., Boni-Schnetzler M., Pilch P.F., et al. Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor І in vitro // J Clin Invest. - 1988. - Vol. 82. - P. 950-957.
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