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Abstract
Objective. Evaluate the effectiveness of superselective chemoembolization of tumor vessels in combination with chemotherapy and radiation therapy in patients with locally advanced malignant tumors of nasopharynx (NC).
Methods. A retrospective study with prospective follow-up was conducted, divided into two groups: in the СE+CRT group, the first stage was superselective chemoembolization of tumor vessels followed by combined chemoradiotherapy (CRT), adjuvant chemotherapy (AT), in the CRT group - CRT followed by AT. Effectiveness was evaluated by event-free survival (EFS) and overall survival (OS) 1 and 2 years after treatment.
Results. The study included 71 patients(28 patients with CE+CRT, 43 CRT). Average follow–up time for EFS was 29 months (IQR 12 - 50 months). One-year EFS was 88.7%(95%CI [69.0 – 96.2]) in the CE+CRT group, 76.5% (95%CI [60.8 – 86.6]) in the CRT group (p<0.01). One–year OS for the CE+CRT group was 96.3% (95%CI [76.5 - 99.5]), CRT group - 83.7% (95%CI [68.9 – 91.9])(p=0.03). Male sex is an independent clinical factor influencing the reduction of EFS (HR 3,734; 95%CI [1,262 – 11,050];p=0.02).
Conclusions. Our results show that chemoembolization of nasopharyngeal malignant tumor vessels provides an acceptable response rate in patients with locally advanced nasopharyngeal tumors and allows for chemotherapy in full doses, remote chemoradiotherapy in radical doses without long breaks. Further studies are needed to assess local control of nasopharyngeal tumors after treatment.
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