Keywords
prognosis
human papillomavirus (HPV)
high carcinogenic risk
integration of HPV DNA
cervical cancer (CC)
How to Cite
Abstract
There was performed a comparative analysis of quantitative load and physical status of human papillomavirus (HPV) type 16 in groups of patients with cervical intraepithelial neoplasia (CIN) - 25 people and cervical cancer (CC) - 85 people. According to the analysis there were selected criteria appropriate to a combination of adverse factors that characterized HPV-infection and at the same time estimated both quantitative load and physical status of the virus: high viral load (> 6,5 lg copies of HPV DNA per 100000 cells) in episomal form or low load (<6,5 lg copies of HPV DNA per 100000 cells) in integrated form of the virus. According to calculations a relative chance of appearing of CC in CIN patients with unfavorable combination of factors was 7,5 times higher than in other patients.References
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