THE RESULTS OF CHEMORADIOTHERAPY FOR LOCALLY ADVANCED LARYNGEAL CANCER WITH HYPERFRACTIONATED RADIATION MODE

Abstract

Single chemoradiotherapy (CRT) was performed in 27 patients with laryngeal cancer (T3-4N0-3M0). Radiotherapy (Rt) was carried out in hyperfractionated mode 1+1 Gy (every 4-5 hours), 5 times a week to CFD 60 Gy with a 2-week break after CFD 30-40 Gy. Courses of polychemotherapy (PCT) were performed simultaneously with RT at each stage of treatment. Overall 5-year survival of patients in the whole by the group (T3-4N0-3) was 44.6 % , for patients with T3N0 - 72,7 %, T3N1-2 - 42,9 %, T4N1-2 - 40.0 % with an average life expectancy 38.1; 50.8; 39.0 and 39.8 months respectively. During a 5-year follow-up the local control of the primary tumor at T3 was equal to 61 %, T4 - 25 % with a median remission of 40.6 and 13.5 months respectively. During this period the regional control at metastases N1 was 50 %, with a median remission of 32.7 months. In 4 patients of 5 with N2 and in all 3 patients with N3 during the first year after CRT continued growth or tumor recurrence was diagnosed. Thus, conservative CRT provides relatively satisfactory 5-year outcomes in patients with tumors T3N0-1.