Abstract
This review represents the latest data about rare type of ovarian neoplasms - stromal cell tumors, which are 7-8% of all ovarian neoplasias. This group of diseases is characterized by an ambiguous prognosis and high recurrence rate. The paper presents a general characteristic of an emergency treatment, describes the most common and rare nosologicalal forms. The recent diagnostic and therapeutic approaches are characterised. The authors have shown in detail the problems in early diagnosis of primary stromal cell ovarian tumors and their relapses, the lack of a unified approach in therapeutic tactics and the nessesity for further investigations of this group of ovarian neoplasms.
References
Аксель Е.М. Заболеваемость и смертность от злокачественных новообразований органов женской репродуктивной системы в России. Онкогинекология. 2015;1:6-15 [Aksel` E.M. Morbidity and mortality from malignant neoplasms of the female reproductive system in Russia. Oncogynecology. 2015;1:6-15 (In Russ.)].
Li W., Wu X., Fang C. et al. Prognostic factors in adult granulosa cell tumor of the ovary. Saudi Med J. 2009;30(2):247-252.
Hanley K.Z., Mosunjac M.B. Practical Review of Ovarian Sex Cord-Stromal Tumors. Surg Pathol Clin. 2019;12(2):587-620. doi: 10.1016/j.path.2019.02.005.
Young R.H. Ovarian sex cord-stromal tumours and their mimics. Pathology. 2018;50(1):5-15. doi: 10.1016/j.pathol.2017.09.007.
Schneider D.T., Calaminus G., Harms D. et al. Therapy of advanced ovarian juvenile granulosa celltumors. Klin Padiatr. 2002;214(4):173-178. doi: 10.1055/s-2002-33183.
Ray-Coquard I., Brown J., Harter P. et al. Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors. Int J Gynecol Cancer. 2014;24(9 Suppl 3):S42-47. doi: 10.1097/IGC.0000000000000249.
Анурова О.А. Морфологические особенности опухолей стромы полового тяжа яичников. Дис. … канд. мед. наук. 2000 [Anurova O.A. Morphological features of ovarian genital stromal tumors. Dis. … сand. med. sci. 2000 (In Russ.)].
Бейшембаев А.М., Любимова Н.В., Абаев В.М., Жорданиа К.И. и др. Применение ингибина B при рецидивах гранулезоклеточных опухолей яичников. Опухоли женской репродуктивной системы. 2010;3:68-72 [Bejshembaev A.M., Lyubimova N.V., Abaev V.M., Zhordania K.I. et al. Use of inhibin B in relapses of ovarian granulosa cell tumors. Tumors of the female reproductive system. 2010;3:68-72 (In Russ.)].
Жорданиа К.И., Герштейн Е.С., Кушлинский Н.Е. и др. Опухоли яичников. Клиническая онкогинекология. Под ред. В.П. Козаченко. 2005;220–269 [Zhordania K.I., Gershtejn E.S., Kushlinskij N.E. et al. Ovarian tumors. Clinical gynecological oncology. Edited by V.P. Kozachenko. 2005;220–269 (In Russ.)].
Бейшембаев А.М. Рецидивы и метастазы гранулезоклеточных опухолей яичников. Автореф. дисс. … канд. мед. наук. 2011 [Bejshembaev A.M. Relapses and metastases of granulosa cell tumors of the ovaries. Abstract diss. … cand. med. sci. 2011 (In Russ.)].
Карселадзе А.И. Морфология неэпителиальных опухолей яичников: Методические рекомендации. МНИОИ им. П.А. Герцена. 1994 [Karseladze A.I. Morphology of non-epithelial ovarian tumors: Methodical recommendations. MNIOI im. P.A. Gercena. 1994. (In Russ.)].
Кержковская Н.С., Жорданиа К.И., Калистов И.Е. и др. Объем хирургического вмешательства при гранулезоклеточной опухоли яичников. Акуш и гинекол. 2003;5:36-41 [Kerzhkovskaya N.S., Zhordania K.I., Kalistov I.E. et al. The volume of surgical intervention for granulosa cell tumor of the ovaries. Obstet and gynecol. 2003;5:36-41. (In Russ.)].
Scully R.E., Young R.H., Clement P.B. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. Atlas of tumor pathology. Bethesda;Maryland:1998.
Uygun K., Audiner A., Saip P. et al. Granulosa cell tumor of the ovary: retrospective analysis of 45 cases. Am J Clin Oncol. 2003;26(5):517-521. doi: 10.1097/01.coc. 0000037918.88451.6.
Адамян Р.Т. Рак эндометрия у больных гормонпродуцирующими опухолями яичников. Материалы симпозиума. СПб.:H.-JI. 1988 [Adamyan R.T. Endometrial cancer in patients with hormone-producing ovarian tumors. Symposium materials. SPb.:H.-JI. 1988 (In Russ.)].
Цекалова М.А., Кержковская Н.С., Жорданиа К.И. Эхографическая картина гранулезоклеточной опухоли яичников. Эхография. 2002;3:299-310 [Cekalova M.A., Kerzhkovskaya N.S., Zhordania K.I. Echographic picture of ovarian granulosa cell tumor. Echography. 2002;3:299-310 (In Russ.)].
Gebhart J.B., Roche P.C., Keeney G.L. et al. Assessment of inhibin and p53 in granulose cell tumor of the ovary. Gynecol Oncol. 2000;77(2):232-236. doi: 10.1006/gyno. 2000.5774.
Alam K., Maheshwari V, Rashid S. et al. Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. Indian J Pathol Microbiol. 2009;52(1):97-99. doi: 10.4103/0377-4929.44981.
Cabrera-Cantú F., Urrutia-Osorio M., Valdez-Arellano F. et al. Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. Arch Gynecol Obstet. 2014;290(4): 791-796. doi: 10.1007/s00404-014-3293-6.
Farinola M.A., Gown A.M., Judson K. et al. Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. Int J Gynecol Pathol. 2007;26(4):375-382. doi: 10.1097/pgp.0b013e31805c0d99.
Jang N.R., Lee D.H., Jang E.J. et al. Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review. J Pathol Transl Med. 2018;52(5):344-348. doi: 10.4132/jptm. 2018.06.28.
Zhang H.Y., Zhu J.E., Huang W. et al. Clinicopathologic features of ovarian Sertoli-Leydig cell tumors. Int J Clin Exp Pathol. 2014;7(10):6956-6964.
Elashry R., Hemida, H., Goda R. et al. Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience. J Exp Ther Oncol. 2013;10(3):181-187.
Haltia U.M., Hallamaa M., Tapper J. et al. Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Müllerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors. Gynecol Oncol. 2017;144(1):83-89. doi: 10.1016/j.ygyno.2016.11.018.
Semczuk A., Skomra D., Gogacz M. et al. Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. Eur J Gynaecol Oncol. 2011;32(6):691-694.
Bahar B., Hu. Z., Szpaderska A. et al. Fatal case of luteinized thecoma with sclerosing peritonitis in a 40-year-old woman. Int J Gynecol Pathol. 2014;33(1):30-34. doi: 10.1097/PGP.0b013e31827d1a65.
Alvarado-Cabrero I., Valencia-Cedillo R., Mohs-Alfaro M. et al. Ovarian dysgerminoma associated with fibrosarcoma: a case report. Int J Gynecol Pathol. 2011;30(5):466-469. doi: 10.1097/PGP.0b013e318217139e.
Wang J., Papanastasopoulos P., Savage P. et al. A Unique Case of Extraovarian Sex-Cord Stromal Fibrosarcoma, With Subsequent Relapse of Differentiated Sex-Cord Tumor. Int J Gynecol Pathol. 2015;34(4):363-368. doi: 10.1097/PGP. 0000000000000151.
Atram M., Anshu, Sharma S. et al. Sclerosing stromal tumor of the ovary. Obstet Gynecol Sci. 2014;57(5):405-408. doi: 10.5468/ogs. 2014.57.5.405.
Roth L.M. Ramzy I. Signet ring stromal cell tumor revisited and related signet ring cell lesions of the ovary. Hum Pathol. 2014;45(3):636-642. doi: 10.1016/j.humpath. 2013.09.012.
Tampakoudis P., Zafrakas M., Kostopoulou E. et al. Ovarian Sertoli-Leydig cell tumor with coexisting vaginal angiomyxoma: case report and review of the literature. Eur J Gynaecol Oncol. 2004;25(1):116-118.
Farah-Klibi F., Ben Slama S., Ben Hamouda S. et al. Diagnostic value of immunohistochemistry in ovarian sex cord-stromal tumors. Tunis Med. 2008;86(9):821-826.
Aydin A., Ozkanli S., Zemheri E. et al. Steroid cell tumor of the ovary associated with endometrial adenocarcinoma-a rare case report. Eur J Gynaecol Oncol. 2015;36(3):348-350.
Tai Y.J., Chang W.C., Kuo K.T. et al. Ovarian steroid cell tumor, not otherwise specified, with virilization symptoms. Taiwan J Obstet Gynecol. 2014;53(2):260-262. doi: 10.1016/j.tjog. 2013.04.037.
Ranganath R., Sridevi V., Shirley S.S. et al. Clinical and pathologic prognostic factors in adult granulosa cell tumors of the ovary. Int J Gynecol Cancer. 2008;18(5):929-933. doi: 10.1111/j.1525-1438.2007.01154.x.
Сапожникова М.А., Тебенихин В.С. О рецидивах гранулезоклеточных опухолей яичников. Арх. Патол. 1978;40(6):67-70 [Sapozhnikova M.A., Tebenixin V.S. About relapses of granulosa cell tumors of the ovaries. Arc. Patol. 1978;40(6):67-70 (In Russ.)].
La Marca A., Volpe A., Fauser B.C. et al. The Anti-Mullerian hormone and ovarian cancer. Hum Reprod Update. 2007;13(3):265-273. doi: 10.1093/humupd/dml060.
Cooke I., O'Brien M., Charnock F.M. et al. Inhibin as a marker for ovarian cancer. Br J Cancer. 1995;71(5):1046-1050. doi: 10.1038/bjc.1995.201.
Mom C.H., Engelen M.J., Willemse P.H. et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol. 2007;105(2):365-372. doi: 10.1016/j.ygyno. 2006. 12.034.
Koukourakis G.V., Kouloulias V.E., Koukourakis M.J. Granulosa cell tumor of the ovary: tumor review. Integr Cancer Ther. 2008;7(3):204-215. doi: 10.1177/1534735408322845.
Sehouli J., Drescher F.S., Mustea A. et al. Granulosa cell tumors of the ovary: 10 years follow up data of 65 patients. Anticancer Res. 2004;24(2С):1223-1229.
Hines J.F., Khalifa M.A., Moore J.L. et al. Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 1996;60(3):484-488. doi: 10.1006/gyno. 1996.0078.
Samant R., Fung M.F., Choan E. et al. Palliative radiotherapy for recurrent granulosa cell tumor of the ovary: a report of 3 cases with radiological evidence of response. Gynecol Oncol. 2006;102(2):406-410. doi: 10.1016/j.ygyno. 2006.02.034.
Singh-Ranger G., Sharp A., Crinnion J.N. et al. Recurrence of granulosa cell tumour after thirty years with small bowel obstruction. Int Semin Surg Oncol. 2004;1(1):4. doi: 10.1186/1477-7800-1-4.
Hardy R.D., Bell J.G., Nicely C.J. et al. Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature. Gynecol. Oncol. 2005;96(3):865-869. doi: 10.1016/j.ygyno.2004.10.042.
Young R.H. Ovarian Sex Cord-Stromal Tumours and Their Mimics. Pathology. 2018;50(1):5-15. doi: 10.1016/j.pathol.2017.09.007.
Hanley K.Z., Mosunjac M.B. Practical Review of Ovarian Sex Cord-Stromal Tumors. Surg Pathol Clin. 2019;12 (2):587-620. doi: 10.1016/j.path. 2019. 02.005.
Ray-Coquard I., Brown J., Harter P. et al. Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors. Int J Gynecol Cancer. 2014;24(9Suppl3):42-47. doi: 10.1097/IGC.0000000000000249.

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