THE EFFECTIVENESS OF TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER DEPENDING ON THE FACTORS OF PROGNOSIS

ORIGINAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-4-584-589

Published 01.04.2019

Liana Mkrtchyan⁺⁻
Andrey Kaprin⁺⁻
Sergey Ivanov⁺⁻
G. Kulieva⁺⁻
Lyudmila Krikunova⁺⁻

Liana Mkrtchyan

Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)

Andrey Kaprin

Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)

Sergey Ivanov

Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)

G. Kulieva

Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)

Lyudmila Krikunova

Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)

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Keywords

CERVICAL CANCER
RADIOTHERAPY
CHEMORADIOTHERAPY
PROGNOSTIC FACTORS
MULTIVARIATE ANALYSIS

How to Cite

Mkrtchyan, L., Kaprin, A., Ivanov, S., Kulieva, G., & Krikunova, L. (2019). THE EFFECTIVENESS OF TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER DEPENDING ON THE FACTORS OF PROGNOSIS. Voprosy Onkologii, 65(4), 584–589. https://doi.org/10.37469/0507-3758-2019-65-4-584-589

Abstract

Purpose: to estimate the efficiency of the concurrent chemoradiotherapy (CRT) and radiotherapy (RT) alone for patients with the locally advanced cervical cancer (CC) taking into account prognostic factors.

Material and methods: The research included 335 patients with morphologically verified CC of the П-Ш stage on FIGO: 150 patients underwent RT (group 1): 185 patients - CRT with cisplatin and 5-fluorouracil (group 2). Patients in the group 1 were significantly older than patients of the group 2. The disease of the Stage III, parametric variant of the spread of the tumor, as well as metastatic lesions of the pelvic lymph nodes occurred more frequently in the group 2.

Results: In the group 1 complete response to treatment occurred in 98 cases (52.9%), while in the group 2 demonstrated - 64 (42.7%) patients (p < 0.01). Radioepithelitis of Grade 1 and 2 occurred more frequently in patients underwent CRT in this group haematologic and gastrointestinal toxicity was moderate and severe (p = 0.01). Study of late treatment outcomes with method Kaplan-Meyer demonstrated tendency to increase in indicators on the term of 5 years: the overall survival was 69.7±4.6% and 77.1±3.9 - in the group 1 and 2 respectively; the disease-free survival (DFS) was 69.5±4.5% and 75.1±4.1% - respectively; DFS at the II stage was 81.1±5.3% and 90.9±3.9% - respectively; at the III stage it was 56.4±7.3 and 66.1±5.6% respectively (p > 0.05). The variables that were found to be of independent significance for progression-free survival by multivariate analysis were stage of a disease, type of distribution and a morphological form of a tumor (p < 0.05); the method of treatment was not predictive in the probability of an adverse clinical outcome of locally advanced CC.

Conclusion: RT is an adequate method of treatment for a part of patients with II-III stages of CC of older patients with associated diseases, without reducing quality of life and also results of treatment.

https://doi.org/10.37469/0507-3758-2019-65-4-584-589

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