Keywords
RADIOLOGICAL DIAGNOSTIC METHODS
BIOLOGICAL SUBTYPES
SYSTEMIC TREATMENT
How to Cite
Abstract
Purpose: To create a unified system of accelerated clinical trials of new drugs and regimens for breast cancer (BC).
Materials and methods: The study included 1214 patients with BC of different stages (cT1N1, cT2N1-2, cT2-3N0-2, cT2-3N0-1, cT4N0M0). According to trepan biopsy data and immunohistochemical examination (IHC) expression of ER, PR, HER2, and Ki67 was determined. The expression TUBBßIII, TOP2a, analyzes on the BRCA1/2 mutation was studied. The clinical response to neoadjuvant treatment was determined using the physical method, ultrasonography-elas-tography, mammography, contrast magnetic resonance imaging (MRI) and single-photon emission computer mammotography (SPECT-CT).
Results: The correlation index of complete responses (cCR) and total pathomorphological responses (pCR) according to MRI was 0.80, according to ultrasound - 0.61, mammography - 0.60, palpation - 0.57. The low level of amplification of the TUBßIII mRNA gene with a high level of amplification of the TOP2-a gene is a predictor of the achievement of pCR. The inclusion of a neoadjuvant treatment of triply-negative BC carboplatin in addition to paclitaxel or eribulin increases the frequency of reaching pCR (ypT0/is(yp)N0) from 20.3% to 47%.
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Copyright (c) 2018 Vladimir Semiglazov, Petr Krivorotko, Garik Dashyan, Tatyana Semiglazova, Aleksandr Komyakhov, Yekaterina Busko, Vladislav Semiglazov, Anna Artemeva, Veronika Klimenko, Asel Kudaybergenova, Viktoriya Bashlyk, Andrey Mishchenko, Yelena Zhiltsova, Sergey Yereshchenko, Aleksandra Kondakova, Aleksey Belyaev, Pavel Krzhivitskiy, Ye. Trufanova, A. Tseluyko