Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

SUBSTANTIATION OF THE MODEL FOR CALCULATING THE INDIVIDUAL DOSE OF CYTOSTATICS USING CT VOLUMETRY FOR ISOLATED LUNG CHEMIOPERFUSION WITH METASTASECTOMY

ORIGINAL ARTICLES. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-319-324

Published 01.03.2018

Yevgeniy Levchenko⁺⁻
Konstantin Senchik⁺⁻
Oleg Mamontov⁺⁻
Andrey Mishchenko⁺⁻
Lev Shevkunov⁺⁻
Nikita Levchenko⁺⁻
Elvira Gumbatova⁺⁻
Tatyana Dubinina⁺⁻
P. Kalinin⁺⁻
ChZhAN VEN⁺⁻
VAN TIN⁺⁻
Ya. Ulyanchenko⁺⁻

Yevgeniy Levchenko

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

Konstantin Senchik

N.N. Petrov National Medical Research Center of Oncology

Oleg Mamontov

N.N. Petrov National Medical Research Center of Oncology

Andrey Mishchenko

N.N. Petrov National Medical Research Center of Oncology

Lev Shevkunov

N.N. Petrov National Medical Research Center of Oncology

Nikita Levchenko

N.N. Petrov National Medical Research Center of Oncology

Elvira Gumbatova

N.N. Petrov National Medical Research Center of Oncology

Tatyana Dubinina

N.N. Petrov National Medical Research Center of Oncology

P. Kalinin

N.N. Petrov National Medical Research Center of Oncology

ChZhAN VEN

N.N. Petrov National Medical Research Center of Oncology

VAN TIN

N.N. Petrov National Medical Research Center of Oncology

Ya. Ulyanchenko

N.N. Petrov National Medical Research Center of Oncology

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Keywords

METASTATIC LUNG LESION
ISOLATED LUNG

How to Cite

SUBSTANTIATION OF THE MODEL FOR CALCULATING THE INDIVIDUAL DOSE OF CYTOSTATICS USING CT VOLUMETRY FOR ISOLATED LUNG CHEMIOPERFUSION WITH METASTASECTOMY. (2018). Voprosy Onkologii, 64(3), 319-324. https://doi.org/10.37469/0507-3758-2018-64-3-319-324

Abstract

In order to create conditions for increasing the effectiveness of treatment of patients with metastatic lung disease a new method for calculating the dose of antitumor drug for performing isolated chemo-perfusion of the lung with metasta-sectomy taking into account the anatomical features of patients and previous operations on the lung was developed. The study consisted of three stages. As a result of the first stage of the study the effectiveness of the software package was measured in the volume of lung patients based on the presence of a strong positive correlation between the volumes of left lungs (Rs = 0.91, p <0.001), right lungs (Rs = 0.94, p <0.001) during the primary and repeated CT chest. As a result of the second stage of the study a weakly positive relationship was found between the volume of right lungs and the surface area of patients’ bodies (Rs = 0.32-0.40, p <0.001) and a weakly positive relationship between the volume of left lungs and the surface area of the patients’ bodies (Rs = 0, 32-0,40, p <0,001), which confirms the inexpediency of dosing an antitumor drug for lung chemo-perfusion based on the body surface area of a patient. As a result of the third stage of the study a method for calculating the dose of melphalan and cisplatin for performing lung chemo-perfusion based on CT lung volumetry was developed.

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References

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Copyright (c) 2018 Yevgeniy Levchenko, Konstantin Senchik, Oleg Mamontov, Andrey Mishchenko, Lev Shevkunov, Nikita Levchenko, Elvira Gumbatova, Tatyana Dubinina, P. Kalinin, ChZhAN VEN, VAN TIN, Ya. Ulyanchenko

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