Abstract
Disease progression after surgical treatment is associated with a poor prognosis for patients with gastric cancer. Peritoneal carcinomatosis frequently occurs as a progression pattern that limits the opportunities for systemic chemotherapy. Treating non-metastatic gastric cancer with methods that prevent the development of carcinomatosis could reduce the frequency of progression. The literature review presents completed and ongoing research on regional methods of intraperitoneal chemotherapy used in complex radical treatment to prevent peritoneal carcinomatosis in patients at high risk. The authors conducted a literature search using Scopus, Web of Science, PubMed, and Russian Science Citation Index (RSCI) databases. The analysis included sources indexed in the Scopus and Web of Science databases (99 %), RSCI (1 %), as well as the National Library of Medicine's (NLM) clinical trial databases ClinicalTrials.gov and the US ICH GCP clinical trials registry. Approximately 50 % of the studies were published in the last 5 years. To write this literature review, 62 sources were used.
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