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Abstract
The variety of cells, which are presented in the tumor microenvironment complicate comprehension of their effects. The population of T-helper lymphocytes has also expressed heterogeneity. However it becomes clearer that effects of separate cells are defined by their role in formation together with other participants the corresponding type of immuno-inflammatory reaction in a microenvironment. The follicular T-helper lymphocytes that are in tumor both in the structure of the tertiary lymphoid structures that have the architectonics of the lymph node and outside of them are not an exception. This review presents the history of discovery follicular T-helper cells population and stages of their maturation, describes feature of phenotype and considers heterogeneity inside subset of these cells. Furthermore the data about correlation between follicular T-helper cells and tumor disease are presented.References
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