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Аннотация
Положительным итогом химиотерапии рака является увеличение длительности ремиссии и жизни леченых больных. Но на этом фоне стали проявляться и негативные вторичные эффекты химиотерапии. Эти эффекты снижают качество жизни леченых больных. К ним относятся офтальмологические осложнения. В обзоре приведены клинические данные об офтальмологической токсичности 7 представителей алкилирующих соединений и интерферона, используемых в химиотерапии. Большое внимание в обзоре уделено ретинотоксическим эффектам этих препаратов. Рассмотрен механизм их гено- и цитотоксического действия, роль в этом участников эксцизионной репарации - N-алкиладенин-Днк-гликозилазы и поли(АДФ-рибоза)-полимеразы (PARP1).
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