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Аннотация
Золотосодержащие комплексные соединения (ЗСК) проявляют противоопухолевую активность in vivo на моделях ксенографтов опухолей человека и перевиваемых опухолей животных, а также обладают цитотоксическим эффектом in vitro, установленным на широкой панели клеточных линий опухолей человека. ЗСК эффективны в отношении опухолей, резистентных к соединениям платины. Механизмы действия ЗСК и производных цисплатины имеют существенные различия. Основными мишенями для действия ЗСК, в отличие от соединений платины, являются белки, в том числе митохондриальная тиоредоксин-редуктаза и протеасома 26S, ингибирование которых препаратами золота ведет к индукции апоптоза.
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