ЗОЛОТОСОДЕРЖАЩИЕ КОМПЛЕКСНЫЕ СОЕДИНЕНИЯ - ПРОТИВООПУХОЛЕВЫЕ СВОЙСТВА, МИШЕНИ И МЕХАНИЗМЫ ДЕЙСТВИЯ
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Ключевые слова

ПРОТИВООПУХОЛЕВАЯ ХИМИОТЕРАПИЯ
ЗОЛОТОСОДЕРЖАЩИЕ КОМПЛЕКСЫ
ТИОРЕДОКСИНРЕДУКТАЗА
АУРАНОФИН
АУРУМАКРИЛ

Аннотация

Золотосодержащие комплексные соединения (ЗСК) проявляют противоопухолевую активность in vivo на моделях ксенографтов опухолей человека и перевиваемых опухолей животных, а также обладают цитотоксическим эффектом in vitro, установленным на широкой панели клеточных линий опухолей человека. ЗСК эффективны в отношении опухолей, резистентных к соединениям платины. Механизмы действия ЗСК и производных цисплатины имеют существенные различия. Основными мишенями для действия ЗСК, в отличие от соединений платины, являются белки, в том числе митохондриальная тиоредоксин-редуктаза и протеасома 26S, ингибирование которых препаратами золота ведет к индукции апоптоза.

https://doi.org/10.37469/0507-3758-2018-64-6-697-707
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