How to Cite
Abstract
The review considered the issues of epithelial-mesenchymal transition (EMT) and its role in inflammation, fibrosis, tumor growth. There were analyzed mechanisms and classification of EMT. A comparison of different forms of EMTs was performed. The important role of EMT in the formation of metastasis-initiating cells was noted. There were presented data on the role of fibroblasts in fibrosis of the lung, carcinogenesis. Stimulators and inhibitors of EMTs were summarized. There were considered intracellular paths that were associated with the development of the EMT under the influence of transforming growth factor ß1 (TGF - ß1). It also induced the development of local hypothyroidism, for easy expression of oncofetal genes, which was especially important in tumor growth. Therapy EMT was associated with blocking the actions of TGF - ß1 and was an important area in anticancer therapy.
References
Киясов А.П., Гумерова А.А., Титова М.А. Мезенхимально-эпителиальная трансформация клеток Ито in vitro // Клеточ.технол.в биол.и мед. - 2006. - № 3. - С. 150-153.
Лазаревич Н.Л. Эпителиально-мезенхимальный переход при прогрессии гепатокарцином // Вестник онкол. науч.центра РАМН. - 2003. - № 3. - С. 76-82.
Пучинская М.В. Раковые стволовые клетки, как возможный источник возникновения и прогрессирования опухолей // Вопр.онкол. - 2016. - Т. 62. - № 1. - С. 14-23.
Рубцова С.Н., Васильев Ю.М. Хелатор железа дефероксамин индуцирует эпителиальную трансформацию опухолевых клеток // Докл. РАН. - 2006. - Т. 411. - № 4. - С. 555-557.
Спирина Л.В., Кондакова И.В. Миграция клеток и онкогенез // Росс.онкол.ж-л. -2010. - № 3. - С. 49-53.
Щербаков В.И., Рябиченко Т.И., Скосырева ГА. Идиопатический фиброз легких и апоптотический парадокс // Вестник НГУ, серия биол. клин.мед. - 2011. - Т. 9. - Вып. 3. - С. 219-226.
Ardura J.A., Rayego-Mateos S., Ramila D. et al. Parathyroid hormone-related protein promotes epithelial-mesenchymal transition // jAsN. - 2010. - Vol. 21. - № 2. - P 273-248.
Beirne S.L., Walsh S.M., Fabre A. et al. CXCL 9 Regulates TGF-ß-Induced Epithelial to Mesenchymal Transition in human Alveolar Epithelial Cells // J. Immunol. - 2015. -Vol. 195. - № 6. - P 2788-2796.
Cao Y., Slaney C.Y., Bidwell B.N. BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity // Cancer Res. - 2014. - Vol. 74. - № 18. - P 5091-5102.
Celia-Terrassa T., Kang Y Distinctive properties of metastasis - initiating cells // Genes.dev. - 2016. - Vol. 30. - № 20. - P. 892-908.
Chambers R.C. Abnormal wound healing responses in pulmonary fibrosis: focus on coagulation signaling // Eur. Respir. Rev. - 2008. - Vol. 17. - № 109. - P. 130-137.
Cheng S., Lovett D.H. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation // Am. J. Pathol. - 2003. - Vol. 162. - P. 1937-1949.
Ding W., You H., Dang H. et al. Epithelial-to-mesenchimal transition of murine liver tumor cells promotes invasion-// Hepatology. - 2010. - Vol. 52. - № 3. - P. 945-953.
Fan S., Wang J.A., Yuan R.O. et al. Skatter factor protects epithelial and carcinoma cells against apoptosis induced
ВОПРОСЫ ОНКОЛОГИИ. 2018, ТОМ 64, № 1 by DNA-damaging agents// Oncogene. - 1998. - Vol. 17. - № 2. - P. 131-141.
Felton V.M., Borok Z., Willis B.C. N-acetylcystein inhibits alveolar epithelial-mesenchymal transition // AJP Lung Cell Mol Physiol. - 2009. - Vol. 297. - № 1. - P. 805812.
Huang S.A., Dorfman D.M., Genest D.R. et al. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium // J.Clin.Endocrinol.Metab. - 2003. - Vol. 88. - № 3. - P 1384-1388.
Huang S.A., Mulcahey M.A., Crescenzi A. et al. Transforming growth factor-b promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase // Mol.Endocrinol. - 2005. - Vol. 19. - № 12. - P. 3126-3136.
Huang Y., Fernandez S.V. Goodwin S.at.al. Epithelial to Mesenchymal Transition in Human Breast Epithelial Cell Transformed by 17b- Estradiol // Cancer Res. - 2007. -№ 23. - P 11147-11155.
Jain R., Shaul P.W., Borok Z., Willis B.C. Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-b1 // Amer.J.Respirat.Cell Mol.Biol. - 2007. - Vol. 37. - № 1. - P. 38-47.
Kalluri R., Neilson E.G. Epithelial-mesenchymal transition and its implication for fibrosis // J.Clin.Invest. - 2003. -Vol. 112. - № 12. - P 1776-1784.
Kalluri R., Zeisberg M. Fibroblast in cancer // Nat. Rev. Cancer. - 2006. - Vol. 6. - № 5. - P. 392-401.
Kim K.K., Kugler M.C., Wolters PJ., et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix // PNAS. - 2006. - Vol. 103. - № 35. - P 1318013185.
Kisseleva T., Brenner D.A. Mechanisms of fibrogenesis // Exp.Biol.Med. - 2008. -Vol. 233. - № 2. - P. 109-122.
Koli K., Myllarniemi M., Vuorinen K. et al. Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis // Am.J.Pathol. - 2006. - Vol. 169. - № 1. - P. 61-71.
Kolosionek E., Savai R., Ghofrani H.A. et. al. Expression and activity of phosphodiesterase isoforms during epithelial mesenchimal transition: the role of phosphodiesterase // MBoC. - 2009. - Vol. 20. - № 22. - P 4751-4765.
Li M., Luan F., Zhao Y., Epithelial-mesenchymal transition: An emerging target in tissue fibrosis // Exp.biol.Med. -2016. - Vol. 241. - № 1. - P. 1-13.
Liao C-J, Li P-T, Lee Y-C. et al. Lipocalin 2 induces the epithelial -mesenchymal transition in stressed indometrial. - 2001. - Vol. 147. - № 2. - P. 179-187.
Liu Y Epithelial to mesenchymal transition in renal fibrogenesis:pathologic significance, molecular mechanism and therapeutic intervention // JASN. - 2004. - Vol. 15. - № 1. - P 1-12.
Morrissey J., Hruska K., Guo G. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function //J.Am.Soc.Nephrol. - 2002. - Vol. 13. -№ 1. - P 14-21.
Neilson E.G. PlasticitY., nuclear diapauses, and a requiem for the terminal differentiation of epithelia // JASN. - 2007. - Vol. 18. - № 7. - P 1995-1998.
Okada H., Danoff T.M., Kalluri R., Neilson E.G. Early role of Fsp1 in epithelial-mesenchymal transformation // Am.J.Physiol. - 1997. - Vol. 273. - № 4. - P 563-574.
Pain M., Bermudes O., Lacoste P et. al. Tissue remobiling in chronic bronchial diseases: from epithelial to mesenchymal phenotype // Eur. Respir. Rev. - 2014. - Vol. 23. -№ 731. - P 118-130.
Park S.H., Choi M.J., Song I.K. et al. Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-b-induced epithelial-to-mesenchymal transition // JASN. - 2007. - Vol. 18. - № 5. - P. 1497-1507.
Ramos C., Becerril C., Montano M. et al. FGF-1 reverts epithelial-mesenchymal transition induced by TGF-b1 through MAPK/ERK kinase pathway // AJP-Lung Cell. Mol.Physiol. - 2010. - Vol. 299. - № 2. - P 222- 231.
Scarpa E., Mayor R. Collective cell migration in development // J. Cell Biol. - 2016. - Vol. 212. - № 2. - P. 143 -145.
Schramek H., Feifel E., Marschitz I. et al. Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells // AJP-Cell Physiol. - 2003. - Vol. 285. - № 3. - P. 652-661.
Selman M. Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis // Proc.Amer.Thoracic.Soc. - 2006. -Vol. 3. - № 4. - P. 364-372.
Shen M., Liu X., Zhang H., Guo S-W. Transforming growth factor b1 signaling coincides with epithelial-mesenchymal transition and fibroblast- to -myofibroblast transdifferentiation in the development jf adenomyosis in mice // Human Reproduction. - 2016. - Vol. 31. - № 38. - P. 355-369.
Sheppard D. The role of integrins in pulmonary fibrosis // Eur. Respir. Rev. - 2008. - Vol. 17. - № 109. - P. 157-162.
Shukla M.N., Rose J.L., Ray R., et al. Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad 7//Amer.J.Respir.Cell Mol.Biol. - 2009. -Vol. 40. - № 6. - P. 643-653.
Strutz F., Muller G.A. Transdifferentiation comes of age // Nephrol. Dial.Transplant. -2000. - Vol. 15. - № 11. - P. 1729-1731.
Tan T.K., Zheng G., Hsu T.T. et al. Macrophage matrix me-talloproteinase-9 mediates epithelial -mesenchymal transition in vitro in murine renal tubular cells // Amer.J.Pathol. - 2010. - Vol. 176. - № 3. - P 1256-1270.
Thomas D.A.,Massague J. TGF-beta directly targets cytoxic T cell functions during tumor evasion on immune surveillance // Cancer Cell. - 2005. - Vol. 8. - № 5. - P. 369-380.
Valcz G., Sipos F., Tulassay Z. republished: Importanse of carcinoma -associated fibroblast-derived proteins in clinical oncology // Postgrad Med. J. - 2015. - Vol. 91. -№ 1075. - P. 1026-1031.
Vyas-Read S., Shaul P.W., YuhannaYS., Willis B.C. Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cell // AJP Lung Cell.Mol.Physiol. - 2007. - Vol. 293. - № 1. - P 1212-1221.
Wang S., Chen Q., Simon T C. et al. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy // Kidney Int. - 2003. - Vol. 63. - № 6. - P. 20372049.
Willis B.C., Liebler J.M., Luby-Phelps K. et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis // Am.J.Pathol. - 2005. -Vol. 166. - № 5. - P 1321-1332.
Willis B.C., Borok Z. TGF-b-induced EMT: mechanisms and implications for fibrotic lung disease // AJP Lung Cell. Mol.Physiol. - 2007. - Vol. 293. - № 3. - P 525-534.
Wipff P.J., Rifkin D.B., Meister J.J., Hinz B. Myofibroblast contraction activates latent TGF-b1 from the extracellular matrix // JCB. - 2007. - Vol. 179. - № 36. - P 1311-1323.
Yang J., Liu Y Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis // Am.J.Pathol. - 2001. - Vol. 159. - № 4. - P 1465-1475.
Yang J., Dai C., Liu Y. Hepatocyte growth factor gene therapy and angiotensin 11 blockade synergistically attenuate renal interstitial fibrosis in mice // J.Am.Soc.Nephrol. - 2002. - Vol. 13. - № 10. - P 2464-2477.
Yang J., Liu Y. Blockade of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis // J.Am.Soc.Nephrol. - 2002. - Vol. 13. - № 1. - P 96-107.
Yang Y.L., Lin Y.S., Chuang L.Y., Guh J.Y. et al. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type 1 transforming growth factor-b receptors // Endocrinology. - 2009. - Vol. 150. - № 32. - P. 727-740.
Xiong Y., Xiong W.,Shang L. et al. hypoxia-inducible factor 1a-inducid epithelial-mesenchymal transition of endometrial epithelial cells may contribute to the development of endometriosis // Hum.Reprod. - 2016. - Vol. 31. - № 6. - P 1327-1338.
Zeisberg M., Shah A.A., Kalluri R. Bone morphogenetic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney // J.Biol.Chem. - 2005. - Vol. 280. - № 9. - P 8094-8100.
Zeisberg M., Yang C., Martino M.et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition // J.Biol.Chem. - 2007. - Vol. 282. -№ 32. - P. 23337-23347.
Zhang A., Wang M.H., Dong Z., Yang T. Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction wich hepatocyte growth factor // AJP -renal Physiol. - 2006. - Vol. 291. - № 6. - P. 1323-1331.
Zhang A., Jia Z., Guo X., Yang T. Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin // AJP-Renal Physiol. - 2007. - Vol. 293. - № 3. -P 723-731.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.