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Abstract
Background. Hormones and their receptors are important effectors providing interconnection between the primary tumor and metastatic niches.
The aim of the study was to determine levels of prolactin (PRL), sex steroid binding globulin (SSBG), steroid hormones and their receptors in tissues of gastric cancer (GC), omentum and peritoneum.
Materials and methods. Levels of PRL, SSBG, steroid hormones and their receptors were determined by ELISA in tissues of primary tumors, omentum and peritoneum in main groups: 1 (M0) — GC T3–4аN0–3M0 (n=24) and 2 (M1) — GC T3–4аN0–3M1 (n=21); in tissues of the stomach, omentum and peritoneum — in the comparison group — non-cancer patients (n=17).
Results. GC (М0) was characterized by high levels of estrogen receptors (ER) α — by 1.2 times (p<0.05), progesterone (PR) — by 3.5 times and SSBG — by 1.4 times (p<0.05); tissues of the omentum and peritoneum showed increased levels of ERα — by 2.4 and 3.9 times, ERβ — by 1.5 (p<0.05) and 2.5 times, РR — by 2.2 and 1.5 times (p<0.05). GC (М1) had low ERα levels; in tissues of GC, omentum and peritoneum, estradiol was reduced — by 4.2, 4.0 and 8.6 times, respectively, free testosterone increased — by 18.9, 2.0 and 2.8 times, and PRL increased by 8.0, 7.6 and 1.7 times (p<0.05).
Conclusions. Elevated levels of receptors ERα, ERβ and РR in metastatic niches in GC can be considered one of the factors protecting tissues from metastatic colonization, and levels of ERα and РR in the niches correlate with their levels in tumor tissues in GC М1 and М0.
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