Fallopian tube carcinoma: clinical and morphological features, analysis of 69 cases

Abstract

Primary fallopian tube carcinoma (PFTC) is a rare gynecological malignancy accounting 0.14-1.8 % cases. The purpose of the study was to assess clinical, morphological and immunohistochemical features of PFTC. All the cases of PFTC were detected during 1980-2005. 31 cases of PFTC were analyzed as to Ki-67, HER-2 expression, estrogen receptors (ER), progesterone receptors (PR), grade and stage. 69 cases of PFTC were detected with an average age of 55,6 years (range 21-73 years). Stage I detected in 34,2 % cases, Stages II и III - 32,8 %, Ca in situ - 10 %. Among 31 patients ER were positive in 75 % (n=23), PR were positive in 46 % (n=14): ER+PR+ in 12 (38 %) cases, ER+PR- in 11 (36 %) cases, ER-PR+ in 2 (6 %) cases, ER-PR- in 6 (19,4 %) cases. Only 2 cases were HER-2 positive with ER+PR+ and ER-PR- status. Ki-67 labeling index (LI, %) values ranged from 15 to 95 % (median 60) with average rate 58,03 %±4,08. Ki-67 LI values > 60 % were graded as high and < 60 % as low. We did not find any significant differences in Ki-67 LI values among tumors of various Receptor Status. However Ki-67 L1 > 60 % was associated with poor 5-year survival (14 %), vs 75 % in Ki-67 L1 < 60 %. Primary fallopian tube carcinoma is mainly HER-2 negative, receptor positive in 79,6 %. Ki-67 rate is irrespective of ER PR status. However the level of Ki-67 (>60 %) was a significant survival prognostic factor.