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Abstract
The detection of mutations in the BRCA1/2 genes has become an integral component of modern oncology. Many essential aspects related to the diagnosis of hereditary tumor syndromes, e.g., principles of patient selection for BRCA1/2 analysis, minimal requirements for DNA testing procedures, medical interventions applied to mutation carriers, remain the subject of confusion among practicing oncologist and laboratory specialists. This work is the result of a discussion on various nuances of BRCA1/2-diagnostics, which was organized by the Russian Society of molecular geneticists in oncology and oncohematology and specialists with extensive experience in cancer genetics.
References
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