How to Cite
Abstract
- Assessment of the contribution of polymorphic loci for genes from glutationtransferases family (GSTM1, GSTP1, GSTT1 genes) and their intergenic interactions to the formation of predisposition to cervical cancer (CС) in women of Kyrgyz nationality.
- Materials and methods. The study included 191 women of the Kyrgyz ethnic group. Among them there were 95 women with the morphologically verified diagnosis of cervical cancer (СC), and 96 women without oncological diseases in their medical history. Genotyping of single-nucleotide polymorphisms (SNPs) was performed using PCR-RFLP for rs1695 GSTP1 Deletion polymorphisms in GSTT1 and GSTM1 genes were determined using allele-specific real-time PCR.
- Deletion of the GSTM1 gene region was a genetic marker associated with an increased likelihood of developing СС (odds ratio (OR)=2.02, 95% CI 1.28–3.20, p=0.002) among the examined women from Kyrgyzstan. Similar results were obtained for GSTT1 gene ― the deletion of the GSTT1 gene region was also a genetic marker associated with an increased likelihood of developing СС (OR=3.04, 95% CI 2.00–4.64, p<0.0001). Analysis of the polymorphic variant p.Ile105Val (GSTP1 gene) did not reveal statistically significant differences in the frequency of genotypes or alleles distribution between cervical cancer patients and women from the comparison group (p>0.05).
- The results of the present study confirm the association of combined carrier state of particular variants of GSTM1 and GSTT1 genes and higher likelihood of CC development in Kyrgyz women.
References
Cervical Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012. WHO, 2015. URL:http://globocan.iarc.fr/old/FactSheets/cancers/cervix-new.asp (access date: 01.07.2022).
Arbyn M, Tommasino M, Depuydt C, Dillner J. Are 20 human papillomavirus types causing cervical cancer? // J Pathol. 2014;234(4):431–435. doi:10.1002/path.4424
Bruni L, Albero G, Serrano B et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 17 June 2019. URL:https://www.hpvcentre.net/statistics/reports/XWX.pdf (access date: 01.07.2022).
Kim JW, Roh JW, Park NH et al. Polymorphism of TP53 codon 72 and the risk of cervical cancer among Korean women // Am J Obstet Gynecol. 2001;184(2):55–58. doi:10.1067/mob.2001.108329
Martínez-Nava GA, Fernández-Niño JA, Madrid-Marina V, Torres-Poveda K. Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent Evidence // Plos one. 2016;11(7):e0157344. doi:10.1371/journal.pone.0157344
Roszak A, Lianeri M, Jagodzinski PP. Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma // Int J Biol Markers. 2011;26(4):216–220. doi:10.5301/JBM.2011.8581
Jiang Y, Hu SY, Hernandez Donoso L et al. A Systematic Literature Review on Risk Factors for Cervical Cancer in Chinese Population // Value Health. 2014;17(7):733–734. doi:10.1016/j.jval.2014.08.098
Пузырев В.П., Кучер А.Н. Эволюционно-онтогенетические аспекты патогенетики хронических болезней человека // Генетика. 2011;47(12):1573–1585 [Puzyrev VP, Kucher AN. Evolutionary ontogenetic aspects of pathogenetics of chronic human diseases // Russian Journal of Genetics. 2011;47(12):1395–1405 (In Russ.)].
Brown MA, Leo PJ. Genetic susceptibility to cervical neoplasia // Papillomavirus Res. 2019;7:132–134. doi:10.1016/j.pvr.2019.04.002
Chen D, Juko-Pecirep I, Hammer J et al. Genome-wide association study of susceptibility loci for cervical cancer // J Natl Cancer Inst. 2013;105(9):624–633. doi:10.1093/jnci/djt051
Leo PJ, Madeleine MM, Wang S et al. Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study // PLoS Genet. 2017;13(8):e1007257. doi:10.1371/journal.pgen.1006866
Афанасьева И.С., Спицын В.А. Наследственный полиморфизм глутатион-S-трансферазы печени человека в норме и при алкогольном гепатите // Генетика. 1990;26:1309–1315 [Afanasyeva IS, Spitsyn VA. Glutathione S-transferase hereditary polymorphism in normal and alcoholic hepatitis liver // Russian Journal of Genetics. 1993;14:1479–1481 (In Russ.)].
Phuthong S, Settheetham-Ishida W, Natphopsuk S, Ishida T. Genetic Polymorphism of the Glutathione S-transferase Pi 1 (GSTP1) and Susceptibility to Cervical Cancer in Human Papilloma Virus Infected Northeastern Thai Women // Asian Pac J Cancer Prev. 2018;19(2):381–385. doi:10.22034/APJCP.2018.19.2.381
Settheetham-Ishida W, Yuenyao P, Kularbkaew C et al. Glutathione S-Transferase (GSTM1 and GSTT1) polymorphisms in cervical cancer in Northeastern Thailand // Asian Pacific J Cancer Prev. 2009;10:365–368.
Sun P, Song WQ. GSTM1 null genotype and susceptibility to cervical cancer in the Chinese population: An updated meta-analysis // J Cancer Res Ther. 2016;12(2):712–715. doi:10.4103/0973-1482.154004
Raunio H, Husgafvel-Pursiainen K, Anttila S et al. Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility ― a review // Gene. 1995;159:113–121. doi:10.1016/0378-1119(94)00448-2
Baranov VS, Ivaschenko T, Bakay B et al. Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases // Hum. Genet. 1996;97:516–520. doi:10.1007/bf02267078
Ryberg D, Skaug V, Hewer A et al. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk // Carcinogenesis. 1997;18:1285–1289. doi:10.1093/carcin/18.7.1285
Смирнова Е.Г., Кипень В.Н., Мельнов С.Б., Мохорт А.А. Полиморфизм генов глутатион-S-трансфераз при раке почки // Молекулярная и прикладная генетика. 2017;23:75–82 [Smirnova EG, Kipen VN, Melnov SB, Mokhort AA. Glutathion-S-transferase gene polymorphism in renal cancer // Molecular and Applied Genetics. 2017;23:75–82 (In Russ.)].
Исакова Ж.Т., Кипень В.Н., Букуев Н.М. и др. Ассоциация полиморфизма генов TP53 и XRCC1 с наличием ВПЧ 16 и 18 типов и уровнем онкомаркеров в крови у женщин с раком шейки матки // Медицинская генетика. 2019;7:26–33 [Isakova ZhT, Kipen VN, Bykyev NM et al. Association between polymorphisms in tp53 and xrcc1 genes and the high-risk HPV and tumor markers in women with cervical cancer // Medical genetics. 2019;7:26–33 (In Russ.)]. doi:10.25557/2073-7998.2019.07.26-33
Joseph T, Chacko P, Wesley R et al. Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: Associations with tumor progression, age and human papillomavirus infection // Gynecologic Oncology. 2006;101(3):411–417. doi:10.1016/j.ygyno.2005.10.033
Palma S, Novelli F, Padua L et al. Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk // J Cancer Res Clin Oncol. 2010;136:1101–1109. doi:10.1007/s00432-009-0757-3
Djansugurova LB, Perfilyeva AV, Zhunusova GS et al. The determination of genetic markers of age-related cancer pathologies in populations from Kazakhstan // Frontiers in Genetics. 2013;4:70. doi:10.3389/fgene.2013.00070
Natphopsuk S, Settheetham-Ishida W, Settheetham D, Ishida T. Lack of participation of the GSTM1 polymorphism in cervical cancer development in Northeast Thailand // Asian Pacific Journal of Cancer Prevention. 2015;16(5):1935–1937. doi:10.7314/apjcp.2015.16.5.1935
Kiran B, Karkucak M, Ozan H et al. GST (GSTM1, GSTT1 and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer // J Gynecol Oncol. 2010;21(3):169–173. doi:10.3802/jgo.2010.21.3.169
Stosic I, Grujicic D, Arsenijevic S et al. Glutathione S-transferase T1 and M1 polymorphisms and risk of uterine cervical lesions in women from central Serbia // Asian Pacific Journal of Cancer Prevention. 2014;15(7):3201–3205. doi:10.7314/apjcp.2014.15.7.3201
Sierra-Torres CH, Arboleda-Moreno YY, Orejuela-Aristizabal L. Exposure to wood smoke, HPV infection and genetic susceptibility for cervical neoplasia among women in Colombia // Environmental and Molecular Mutagenesis. 2006;47(7):553–561. doi:10.1002/em.20228
Economopoulos KP, Choussein S, Vlahos NF, Sergentanis TN. GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: A meta-analysis // Int J Gynecol Cancer. 2010;20:1576–1580. doi:10.1111/IGC.0b013e3181ca1dfc
Gao LB, Pan XM, Li LJ et al. Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: An evidence-based meta-analysis // PLoS One. 2011;6(5):e20157. doi:10.1371/journal.pone.0020157
Liu Y, Xu LZ. Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer // Asian Pac J Trop Med. 2012;5:480–484. doi:10.1016/S1995-7645(12)60083-2
Sui Y, Han W, Yang Z et al. Association of glutathione S-transferase M1 and T1 null polymorphisms with the development of cervical lesions: A meta-analysis // Eur J Obstet Gynecol Reprod Biol. 2011;159:443–448. doi:10.1016/j.ejogrb.2011.09.012
Wang D, Wang B, Zhai JX et al. Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis // Neoplasma. 2011;58:352–359. doi:10.4149/neo_2011_04_352
Zhang ZY, Jin XY, Wu R et al. Meta-analysis of the association between GSTM1 and GSTT1 gene polymorphisms and cervical cancer // Asian Pac J Cancer Prev. 2012;13:815–819. doi:10.7314/apjcp.2012.13.3.815
Zhen S, Hu CM, Bian LH. Glutathione S-transferase polymorphism interactions with smoking status and HPV infection in cervical cancer risk: An evidence-based meta-analysis // PLoS One. 2013;8(12):e83497. doi:10.1371/journal.pone.0083497
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2022