MICROVISCOSITY OF ERYTHROCYTE MEMBRANES IN BREAST CANCER PATIENTS: CONNECTION WITH THE RECEPTOR PHENOTYPE OF THE TUMOR
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Keywords

breast cancer
hormone dependence
viscosity of erythrocyte membranes

How to Cite

, , , , , , , & . (2014). MICROVISCOSITY OF ERYTHROCYTE MEMBRANES IN BREAST CANCER PATIENTS: CONNECTION WITH THE RECEPTOR PHENOTYPE OF THE TUMOR. Voprosy Onkologii, 60(4), 505–510. https://doi.org/10.37469/0507-3758-2014-60-4-505-510

Abstract

The state of the viscosity of erythrocyte membranes in breast cancer patients (68 - in menopause and 32 - with saved menstrual cycle) was studied in comparison with the content of steroid hormone receptors in the tumor tissue and the age of patients. It is showed that the less hormone dependence of the tumor the higher viscosity of erythrocyte membranes that manifested by a decrease in the coefficient of eximerization (CE) of pyrene in the protein/lipid and in particular, lipid/lipid membrane layers. Increasing CE of pyrene in lipid/lipid layer of erythrocyte membranes above 1.7 units, reflecting a decline in their microviscosity, could be considered as an additional extra-tumor criterion for identification of the tumor as of hormone dependent type.
https://doi.org/10.37469/0507-3758-2014-60-4-505-510
PDF (Русский)

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