THE EFFECT OF SODIUM FLUOROACETATE AND METFORMIN ON THE ANTITUMOR ACTIVITY OF CYCLOPHOSPHAMIDE ON THE AUTOCHTHONOUS MICE SARCOMA MODEL
Vol. 60 No. 4 (2014), Articles
Vol. 60 No. 4 (2014)

THE EFFECT OF SODIUM FLUOROACETATE AND METFORMIN ON THE ANTITUMOR ACTIVITY OF CYCLOPHOSPHAMIDE ON THE AUTOCHTHONOUS MICE SARCOMA MODEL

Articles
https://doi.org/10.37469/0507-3758-2014-60-4-515-517
Published 15.12.2014
N.N. Petrov Research Institute of Oncology
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry
N.N. Petrov Research Institute of Oncology
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
PDF (Русский)

Keywords

sodium fluoroacetate
metformin
antitumor activity
induced sarcoma
mice

How to Cite

, , , , , , , & . (2014). THE EFFECT OF SODIUM FLUOROACETATE AND METFORMIN ON THE ANTITUMOR ACTIVITY OF CYCLOPHOSPHAMIDE ON THE AUTOCHTHONOUS MICE SARCOMA MODEL. Voprosy Onkologii, 60(4), 515–517. https://doi.org/10.37469/0507-3758-2014-60-4-515-517
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Abstract

Previously it was found that sodium fluoroacetate (SF) inhibited the growth of the Ehrlich cancer by means of monotherapy and enhanced the antitumor effect of cyclophosphamide (CP) in experiments with autochthonous subcutaneous tumors induced by benzo (a) pyrene. In this study a comparison of the antitumor activity of SF and metformin showed that both substances did not have significant effect in monotherapy but enhanced the effect of CP, increasing the percentage of tumors with the same or reduced volume. Besides, SF, unlike metformin increased the average duration of effect. The data obtained promoted further study of the mechanism of the antitumor effect of SF and the search effective combination with already known antitumor drugs.
https://doi.org/10.37469/0507-3758-2014-60-4-515-517
PDF (Русский)

References

Аникин И.В., Гончаров Н.В., Тындык М.Л. и др. Влияние фторацетата натрия на рост солидного рака Эрлиха и аутохтонных сарком мышей // Вопр. онкол. - 2013. - Т. 3. - С. 777-780.

Зинченко В.П., Гончаров Н.В., Теплова В.В. и др. Изучение взаимосвязи внутриклеточных сигнальных и метаболических путей при ингибировании митохондриальной аконитазы фторацетатом // Цитология. - 2007. - Т. 49. - № 12. - С. 1041-1050.

Anisimov V.N. Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer // Aging (Albany NY). - 2013. - Vol. 5. - N. 5. - P. 337-338.

Anisimov V.N., Bartke A. The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer // Critical Reviews in Oncology / Hematology. - 2013. - Vol. 87. - P. 201-203.

Goncharov N.V., Jenkins R.O., Radilov A.S. Toxicology of fluoroacetate: a review, with possible directions for therapy research // J. Appl. Toxicol. - 2006. - Vol. 26. - N. 2. - P. 148-161;

Goncharov N., Glashkina L., Savelieva E. et al. Fluoroacetate // Handbook of the Toxicology of Chemical Warfare Agents. Elsevier Inc. - Oxford. - 2009. - Р. 177-198.

Dietrich L.S., Shapiro D.M. Fluoroacetate and fluorocitrate antagonism of tumor growth; effect of these compounds on citrate metabolism in normal and neoplastic tissue // Cancer Res. - 1956. - Vol. 16. - N. 7. - P. 585-588.

Kirpichnikov D., McFarlane S.I., Sowers J.R. Metformin: an update // Ann. Intern. Med. - 2002. - Vol. 137. - P. 25-33;

Zinchenko V.P., Goncharov N.V., Teplova V.V. et al. Polarographic and spectroscopic studies of the effects of fluoroacetate / fluorocitrate on cells and mitochondria // Spectroscopy Int. J. - 2007. - Vol. 21. - P. 121-134.

All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...