Keywords
How to Cite
Abstract
There were assessed morphofunctional state of peripheral blood neutrophils and cytokine status in the serum of primary patients with progression of cervical cancer in the dynamics. Against the background of increasing the total number of neutrophils it was occurred a significant reduction in the phagocytic activity, aerobic and anaerobic bactericidal activity, an increase of the rigidity of the membrane and the change of cell cytoarchitectonies at Ib-IIa stage of the disease. At the same stage, in neutrophils there were reduced the level of IL-lβ and its receptor IL-IRa as well as the number of IFN-γ. Wherein there was increased the level of pro-inflammatory cytokine TNF-α. Cytokine status of the serum, characterized by significant boosting of IL-IRa and IL-18 while lowering TNF-α, IFN-γ and IL-2, was advantageous for tumor progression and was detected at Ib-IIa stage of cervical cancer. The observed changes of cytokine status in the serum and morphofunctional state of neutrophils were discussed in the light of connection with the possibility of potential pro-tumor effect of the latter.References
Абакумова Т.В., Генинг Т.П., Антонеева И.И. и др. Цитоархитектоника и фагоцитарная активность нейтрофилов больных раком шейки матки при фемтосекундном лазерном излучении in vitro // Вестн. новых мед. технологий. - 2012. - Т. XIX, № 3. - С. 34-37.
Антонеева И.И. Нейтрофильные гранулоциты в динамике прогрессии рака яичников // Клин. лаб. диагностика. - 2007. - № 8. - С. 43-46.
Генинг Т.П., Абакумова Т.В., Антонеева И.И., Генинг С.О. Нейтрофильный статус при раке шейки матки Ia стадии // Вест. РОНЦ им. Н.Н. Блохина РАМН. - 2011. - Т. 22, № 2. - С. 65-68.
Коган А.Х. Фагоцитзависимые кислородные - свободнорадикальные механизмы аутоагрессии в патогенезе внутренних болезней // Вестн. Росс. акад. мед. наук. - 1999. - № 2. - С. 3.
Козлов В.А. Стабильность м-РНК в регуляции уровня экспрессии генов цитокинов и в реализации их регуляторных эффектов // Система цитокинов: Теоретические и клинические аспекты / Под ред. В.А. Козлова, C.B. Сенникова. Новосибирск: Наука, 2004. - 324 с.
Мальцева В.Н., Авхачева Н.В., Санталов Б.Ф., Сафронова В.Г. Наблюдение в динамике модификации функциональной активности периферических нейтрофилов и её регуляции при росте опухоли in vivo // Цитология. - 2006. - Т. 48, № 12. - С. 1000-1009.
Мальцева В.Н., Сафронова В.Г. Неоднозначность роли нейтрофилов в генезе опухоли // Цитология. - 2009. - № 6. - С. 467-474.
Нестерова И.В., Швыдченко И.Н., Роменская В.А. Нейтрофильные гранулоциты - ключевые клетки иммунной системы // Аллергология и иммунология. - 2008. - Т. 9, № 4. - С. 432-436.
Плескова С.Н., Звонкова М.Б., Гущина Ю.Ю. Использование метода сканирующей зондовой микроскопии для исследования морфологических параметров нейтрофильных гранулоцитов // Морфология. - 2005. - Т. 127, № 1. - С. 60-62.
Chuluyan H.E., Lang B.J., Issekutz A.C. Differential mechanisms of neutrophil and monocyte adhesion on neuroblastoma cells: CD18 and VLA-4 integrins mediate adhesion to SK-N-SH, but not to SK-N-MC cell line // J Neurosci Res. - 2000. - Vol. 60 (5). - P. 649-655.
Condliffe A.M., Davidson K., Anderson K.E., et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils // Blood. - 2005. - Vol. 106 (4). - P. 1432-1440.
Cossatella M.A. The neutrophil. An emerging regulator of inflammatory and immune response // Chem. Immunol. Allergol. - 2003. - Vol. 83. - Р. 232.
Germenis A.E., Karanikas V. Immunoepigenetics: the unseen side of cancer immunoediting // Immunol Cell Biol. - 2007. - Vol. 85 (1). - P. 55-59.
Graf M.R., Prins R.M., Merchant R.E. IL-6 secretion by a rat T9 glioma clone induces a neutrophil-dependent antitumor response with resultant cellular, antiglioma immunity // J Immunol. - 2001. Vol. 166 (1). - P. 121-129.
Gregory A.D., Houghton A.M. Tumor-associated neutrophils: new targets for cancer therapy // Cancer Res. - 2011. - Vol. 71 (7). - P. 2411-2416.
Guichard C., Pedruzzi E., Dewas C. et al. Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts // J Biol Chem. - 2005. - Vol. 280 (44). - P. 37021-37032.
Hegmans J.P., Hemmes A., Hammad H. et al. Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses // Eur Respir J. - 2006. - Vol. 27 (6). - P. 1086-1095.
Jablonska E., Puzewska W., Marcinczyk M., et al. iNOS expression and NO production by neutrophils in cancer patients // Arch. Immunol. Ther. Exp. (Warsz.). - 2005. - Vol. 53. - P. 170-179.
Klink M., Jastrzembska K., Nowak M. et al. Ovarian cancer cells modulate human blood neutrophils response to activation in vitro // Scand J Immunol. - 2008. - Vol. 68 (3). - P. 328-336.
Mueller M.M., Fusenig N.E. Friends or foes - bipolar effects of the tumour stroma in cancer // Nat Rev Cancer. - 2004. - Vol. 4 (11). - P. 839-849.
Piccard H., Muschel R.J., Opdenakker G. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression // Crit Rev Oncol Hematol. 2012. - Vol. 82 (3). - P. 296-309.
Swann J.B., Smyth M.J. Immune surveillance of tumor // J. Clin. Invest. - 2007. - Vol. 117. - P. 1137-1146.
Suzuki K., Hino M., Kutsuna H. et al. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1beta // J Immunol. - 2001. - Vol. 167. - P. 5940-5947.
Trellakis S., Farjah H., Bruderek K. et al. Peripheral blood neutrophil granulocytes from patients with head and neck squamous cell carcinoma functionally differ from their counterparts in healthy donors // Int J Immunopathol Pharmacol. - 2011. - Vol. 24, № 3. - Р. 683-693.
Wu Q.D., Wang J.H., Condron C. et al. Human neutrophils facilitate tumor cell transendothelial migration // Amer. J. Physiol. Cell. Physiol. - 2001. - Vol. 280. - P. 814-822.
All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...