Shtin, V., Novikov, V., Choynzonov, E., Marchenko, E., Stakheeva, M., Kucherova, T., Menshikov, K., Cheremisina, O., & Gribova, O. (2023). Orbital wall reconstruction with titanium nickelide implants in cancer patients: characteristics of reparative processes and the potential for their management. Voprosy Onkologii, 69(2), 259–267. https://doi.org/10.37469/0507-3758-2023-69-2-259-267

Abstract

Aim. To evaluate the effect of orbital wall reconstruction using titanium-nickelid implant (Ti-Ni implant) on the wound healing after surgery for nasal cavity and paranasal sinus cancers, and the possibility of managing this process.

Materials and methods. The study included 60 patients with stage Т_3-4N_0-1M₀nasal cavity and paranasal sinus cancers who received combined treatment at the Tomsk Cancer Research Institute from 2002 to 2021. All patients were divided into 3 groups according to the type of Ti-Ni implants used for orbital wall reconstruction. Magnetic-laser therapy with a combined MILTA-F device was administered to reduce inflammatory complications in the postoperative cavity for patients in groups 1 and 2. To assess the effect of different implant types on wound healing, dynamic endoscopic visualization was performed on the postoperative cavity, and samples were collected for cytological and histological examination. The efficacy of rehabilitation measures was evaluated based on clinical observations of the wound surface, the characteristics of wound healing process, and the detection of complications. Additionally, changes in the local immunity at the cytokine level were examined.

Results. The study revealed a direct correlation between the implant structure and the number of complications after reconstruction. The highest number of complications was detected when using porous implants (33 %). The use of mesh implants reduced the number of complications to 26 %. The best results were achieved when using the third type of implants, namely thin-profile TiNi implants with shape memory (6 %). In addition, it was found that the use of magneto-laser therapy in the postoperative period contributed to the activation of non-specific defense factors and had a positive effect on the immune status in the wound surface area.

https://doi.org/10.37469/0507-3758-2023-69-2-259-267

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