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Abstract
As the arsenal of drugs available to treat metastatic breast cancer (mBC) expands, there is a need to optimise existing approaches to create the most effective line of therapy. With the advent of novel monoclonal antibody-drug conjugates (ADCs) targeting a specific receptor combined with a cytostatic agent in clinical practice, this question has been raised in relation to the treatment of patients with triple negative (TN) and HER2 low breast cancer. This article reviews the key trials on the efficacy of sacituzumab govitecan and trastuzumab deruxtecan in the context of the latest version of clinical guidelines for the treatment of these types of mBC. The accumulation of practical experience and its generalisation in real-world clinical trials will eventually allow clinical oncologists to formulate a strategy for the consistent use of emerging conjugates.
References
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