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Abstract
In comparative evaluation of hormonal and metabolic status in carriers of genetic markers of potential response to antidiabetic biguanide metformin in groups of patients with diabetes (postmenopausal women with newly diagnosed cancer or without it) as well as in cancer patients without diabetes and healthy women it was found that: a) polymorphisms of a gene transporter 1 of organic cations (OCT1) and a gene of sex hormone-binding globulin SHBG, D356N rs6259 (GA) could not only predict the potential sensitivity to metformin, but their carriers were characterized by certain differences of hormonal and metabolic phenotype; b) similar hormonal and metabolic features were mainly associated with nonsteroidal component and were identified mostly in patients with diabetes with or without newly discovered cancer; c) at the same time the presence of cancer was not an obstacle for orientation to both the hormonal and metabolic and genetic parameters in deciding on the possibility of metformin administration, which, however, needs verification by using the same indicators in conditions of the real use of the drug.References
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