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Abstract
The Hsp27 molecular chaperone in dissonance of expression of receptor Her2/neu on the membrane and amplification of its gene in tumor cells of breast cancer was analyzed. Indicators that reflected the functional state of Hsp27 (phosphorylated status of chaperone, especially its intracellular distribution) were investigated. In the group of overexpression of receptor Her2/neu on the membrane in the absence of amplification of gene cerbB2/neu there was marked decrease in the number of cells with the phosphorylated form of Hsp27 in the cytoplasm as compared to Her2/neu-positive group (Her2/neu(2+/3+)/FISH (+)) and negative group (Her2/neu(0/1+)/ FISH(-)). As a result, a participation of Hsp27 can not be excluded in the phenomenon of dissonance of amplification of gene cerbB2/neu and expression of receptor Her2/neu on the membrane of tumor cells of breast cancer.References
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