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Abstract
The quantitative assessment of absolute number of immunocompetent cells was conducted in peripheral blood in 29 patients with renal cell carcinoma (RCC) during treatment process: while 20 patients underwent laparoscopic radiofrequency ablation (RFA), 9 - laparoscopic resection of the kidney (LRK). In patients who underwent RFA during the month after the procedure there was observed a significant increase of activated T-helper cells and cytotoxic T-lymphocytes (p <0,05) while in patients who underwent LRK such changes were absent. Revealed dynamics of immunological parameters might indicate the activation of cellular immunity under the influence of RFA similar to observed during the process of active specific immunotherapy.References
Ali M.Y., Grimm C.F., Ritter M. et al. Activation of dendritic cells by local ablation of hepatocellular carcinoma // J. Hepatol. - 2005. - Vol. 43. - P. 817-822.
den Brok M.H., Sutmuller R.P., van der Voort R. et al. In situ tumor ablation creates an antigen source for the generation of antitumor immunity // Cancer Res. - 2004. - Vol. 64. - P. 4024-4029.
Hansler J., Wissniowski T.T., Schuppan D. et al. Activation and dramatically increased cytolytic activity of tumor specific T. lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases // World J. Gastroenterol. - 2006. - Vol. 12. - P. 3716-3721.
Mahnken A.H., Rohde D., Brkovic D. et al. Percutaneous radiofrequency ablation of renal cell carcinoma: Preliminary results // Acta Radiol. - 2005. - Vol. 46. - P. 208 -214.
Matuszewski M., Michajlowski J., Michajlowski I. et al. Impact of radiofrequency ablation on PBMC subpopulation in patients with renal cell carcinoma // Urol Oncol. - 2011. - Vol. 29. - P. 724-730.
McGovern F.J., Wood B.J., Goldberg S.N. et al. Radio frequency ablation of renal cell carcinoma via image guided needle electrodes // J. Urol. - 1999. - Vol. 161. - P. 599-600.
Mouraviev V., Joniau S., Van Poppel H. et al. Current status of minimally invasive ablative techniques in the treatment of small renal tumours // Eur. Urol. - 2007. - Vol. 51. - P. 328 -336.
Napoletano C., Taurino F., Biffoni M. et al. RFA strongly modulates the immune system and anti-tumor immune response in metastatic liver patients // Int. J. Oncol. - 2008. - Vol. 32. - P. 481-490.
Nikfarjam M., Muralidharan V., Christophi C. Mechanisms of focal heat destruction of liver tumors // J. Surg Res - 2005. - Vol. 127. - P. 208-223.
Pilla L., Squarcina P., Coppa J. et al. Natural killer and NK-Like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96 // Cancer Res. - 2005. - Vol. 65. - P. 39423949.
Rai R., Richardson C., Flecknell P. et al. Study of apoptosis and heat shock protein (HSP) expression in hepato-cytes following radiofrequency ablation (RFA) // J. Surg. Res. - 2005. - Vol. 129. - P. 147-151.
de Reijke T.M., Bellmunt J., van Poppel H. et al. EORTCGU group expert opinion on metastatic renal cancer // Eur. J. Cancer. - 2009. - Vol. 45. - P. 765-773.
Rughetti A., Rahimi H., Rossi P. et al. Modulation of blood circulating immune cells by radiofrequency tumor ablation // J. Exp. Clin. Cancer Res. - 2003. - Vol. 22. - P. 247-250.
Schueller G., Kettenbach J., Sedivy R. et al. Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo // Int. J. Oncol. - 2004. - Vol. 24. - P. 609-613.
Veltri A., Calvo A., Tosetti I. et al. Experiences in US-guided percutaneous radiofrequency ablation of 44 renal tumors in 31 patients: Analysis of predictors for complications and technical success // Cardiovasc. Intervent. Radiol. - 2006. - Vol. 29. - P. 811-818.
Wissniowski T.T., Hansler J., Neureiter D. et al. Activation of tumorspecific T. lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits // Cancer Res. - 2003. - Vol. 63. - P. 496 -500.
Yu H.C., Moon J.I., Jin Z.W. et al. Effect of radiofrequency ablation of the liver on cell mediated immunity in rats // World J. Surg. - 2005. - Vol. 29. - P. 739-743.
Zerbini A., Pilli M., Penna A et al. Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses // Cancer Res. - 2006. - Vol. 66. - P. 1139-1146.
Zlotta A.R., Wildschutz T., Raviv G. et al. Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: Ex vivo and in vivo experience // J. Endourol. - 1997. - Vol. 11. - P. 251-258.
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