Hormonal and metabolic status of patients with luminal and non-luminal variants of breast cancer

Abstract

The heterogeneous nature of breast cancer (BC), based according to modern concepts, on the existence of individual molecular biological subtypes of the disease causes the need to analyze this problem on the basis of different clinical and laboratory approaches. Study of hormonal and metabolic status of BC patients with different subtypes was performed up to now infrequently and had not yet resulted in any preconceived idea. In this paper we examined a representative group of patients who were divided, mainly on immunohistochemical analysis of tumor material, into groups with luminal A, luminal B, thrice-negative and HER2-positive variant of BC. It was found that a subgroup of luminal B patients was characterized by lowest weight and the lowest content of total and visceral fat in the body. The highest values of these four indicators were peculiar to thrice-negative BC patients with significant difference from patients with luminal B form. It was essential that no differences between comparative groups by levels of insulinemia, glycemia and lipidemia were identified. In comparative evaluation of parameters of reproductive and thyroid function to attempt to detect differences between subgroups also failed to find. In the meantime it was important to pay attention to the fact that the differences between the thrice-negative form of the disease and a process with enhanced expression of HER-2 or between the luminal forms A and B were greater than between united luminal and non-luminal patient’s groups that is significant for future applied studies.