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Abstract
The authors aimed to compare expression of UCP1, aromatase (CYP19), markers of macrophage infiltration (CD68, CD163), omentin and PTEN in omental fat of endometrioid or non-endometrioid endometrial cancer (EC) patients with signs of standard (SO) or metabolically healthy obesity (MHO) by immunohistochemical (IHC) or real-time PCR methods. Totally 57 omental fat samples collected during surgery in EC pts (average age 60.1) were studied. According to IHC data, statistically significant decrease in expression of aromatase and CD68 was revealed in omental fat of MHO patients. Expression of UCP1 demonstrated an inclination to decrease in the same group, simultaneously showing correlation with clinical stage of EC. According to real time PCR data, omentin expression displayed tendency to an increase with increase in body mass index (whole group), clinical stage of EC (in SO subgroup) and serum omentin level (MHO subgroup). No any difference in studied omental fat parameters was discovered between patients with endometrioid and non-endometrioid EC. Thus, omental fat properties in EC patients are associated with obesity phenotype and not with histologic subtype of this cancer. Apparently, the features of omental fat depot characteristic for visceral adipose tissue at least are equal to its attributes as a brown fat compartment. Decrease, according to IHC info, of the estrogen biosynthesis and macrophagal infiltration in omental fat of EC patients with MHO phenotype may indicate additional mechanisms for more favorable in this case clinical course of uterine body cancer. Supported by RFBR grant 15-04-00384.References
Берштейн Л.М. Гетерогенность ожирения и рак: потенциальная роль бурой жировой ткани // Вопр. онкол. - 2012. - Т. 58 (4). - С. 464-472.
Берштейн Л.М., Берлев И.В., Васильев Д.А. и др. Ожирение и особенности рака эндометрия: меняется ли что-нибудь с годами? // Вопр. онкол. 2015. - Т. 61 (4). - С. 575-579.
Бохман Я.В. Рак тела матки. Кишинев: Штиинца, 1972, 202 с.
Auguet T, Quintero Y Riesco D. et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women // BMC Med Genet. - 2011. - Vol. 12. - P. 60.
Brinton LA, Felix AS, McMeekin DS et al. Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial // Gynecol Oncol. - 2013. - Vol. 129 (2). - P 277-284.
Cannon B, Shabalina IG, Kramarova TV et al. Uncoupling proteins: a role in protection against reactive oxygen species--or not? // Biochim Biophys Acta - 2006. - Vol. 1757 (5-6). - P. 449-458.
Chen X Cairns R, Papandreou I. et al. Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect // PLoS One. - 2009. - P 4 (9). - Pe 7033.
Crosbie EJ, Roberts C, Qian W, et al. Body mass index does not influence post-treatment survival in early stage endometrial cancer: results from the MRC ASTEC trial // Eur J Cancer 2012. Vol. 48 (6). - P. 853-864.
Cypess AM, Kahn CR. Brown fat as a therapy for obesity and diabetes // Curr Opin Endocrinol Diabetes Obes. - 2010. - Vol. 17 (2). - P143-149.
Evans T, Sany O, Pearmain P, et al. Differential trends in the rising incidence of endometrial cancer by type: data from a UK population-based registry from 1994 to 2006 // Br J Cancer 2011. - Vol. 104 (9). - P 1505-1510.
Fader AN, Arriba LN, Frasure HE, von Gruenigen VE. Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship // Gynecol Oncol. -2009. - Vol. 114 (1). - P 121-127.
Hill AA, Reid Bolus W, Hasty AH. A decade of progress in adipose tissue macrophage biology // Immunol Rev. - 2014. - Vol. 262 (1). - P134-152.
Joo WD, Schwartz PE, Rutherford T.J. et al. Microscopic Omental Metastasis in Clinical Stage I Endometrial Cancer: A Meta-analysis // Ann Surg Oncol. - 2015. -Vol. 22. - P. 3695-3700.
Klopp AH, Zhang X Solley T, et al. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors // Clin Cancer Res. - 2012. - Vol. 18. - P. 771-782.
MacLaren RE, Cui W, Lu H. et al. Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects // BMC Med Genomics. - 2010. - Vol. 3. - P. 3.
Oberkofler, H., Dallinger G., Y-M. Liu et al. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans // J. Lipid Res. -1997. - Vol. 38. - P 2125-2133.
Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R. et al. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle. - 2013. - Vol. 12 (1). - P. 172-182.
Serralde-Zuniga AE, Guevara-Cruz M, Tovar AR. et al. Omental adipose tissue gene expression, gene variants, branched-chain amino acids, and their relationship with metabolic syndrome and insulin resistance in humans // Genes Nutr. - 2014. - Vol. 9. - P 431.
Setiawan VW, Yang HP, Pike MC, et al. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol. - 2013. - Vol. 31 (20). - P. 2607-2618.
Sherman ME.Theories of endometrial carcinogenesis: a multidisciplinary approach // Mod. Pathol. - 2000. - Vol. 13 (3). - P 295-308.
Smorlesi A, Frontini A, Giordano A, Cinti S. The adipose organ: white-brown adipocyte plasticity and metabolic inflammation. Obes Rev. - 2012. - Vol. 13( Suppl 2).- P 83-96.
Sturm R, An R. Obesity and economic environments // CA Cancer J Clin. - 2014. - Vol. 64 (5). - P. 337-350.
Zemlyak A, Zakhaleva J, Pearl M. et al. Expression of inflammatory cytokines by adipose tissue from patients with endometrial cancer // Eur J Gynaecol Oncol. - 2012. - Vol. 33. - P 363-366.
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