Keywords
How to Cite
Abstract
The paper summarizes and analyzes the results of complex treatment of patients with malignant tumors performed in the N.N.Petrov Research Institute of Oncology using perfusion technologies. Safety and efficacy data on various chemoperfusion is presented: intraperitoneal chemoperfusion combined with cytoreductive surgery in patients with locally advanced and disseminated gastric cancer, recurrent ovarian cancer and pseudomyxoma peritonei; isolated lung perfusion combined with metastasectomy in patients with lung metastases; isolated limb perfusion with/without cytoreduction in patients with locally advanced skin melanoma and locally advanced soft-tissue sarcoma. The conclusion is made that both intraperitoneal and isolated chemoperfusions are not associated with higher incidence of intra- and postoperative morbidity. However safety of the procedures could be increased through optimizing tactics of surgical procedures prior to chemoperfusions. The use of perfusion technologies provides significant survival advantage in patients who can’t benefit from conservative treatment.References
Беляев А.М., Внутрибрюшинная химиотерапия злокачественных опухолей брюшной полости / Беляев А.М., Багненко С.Ф., Рухляда Н.В., СПб.: ЭЛБИ-СПб, 2007. - 254 с.
Гафтон Г. И., Пхакадзе Н.Р., Сенчик К.Ю., Гельфонд В.М. Перспективные методы терапии больных саркомами мягких тканей конечности // Практ. онкология. - 2004. - Т. 5. - № 4. - С. 276-284.
Гусейнов К.Д., Беляев А.М., Сенчик К.Ю. и др. Гипертермическая интраперитонеальная химиотерапия (HIPEC) в лечении рецидивов рака яичника // Вопр. онкол. - 2014. - Т. 60, № 3. - С. 343-347.
Левченко Е.В., Сенчик К.Ю., Барчук А.С. и др. Изолированная химиоперфузия легкого по поводу метастазов солидных опухолей // Онкохирургия. - 2012. - Т. 4, № 3. - С. 46-53.
Татьяничева Н.В., Гафтон Г.И., Егоренков В.В., Сенчик К.Ю. Изолированная регионарная перфузия в лечении больных саркомами мягких тканей конечностей // Вопр. онкол. - 2011. - Т. 56, № 7. - С. 775-778.
Татьяничева Н.В., Гафтон Г.И., Сенчик К.Ю., Егоренков В.В. Метод изолированной регионарной перфузии в лечении больных с местно-распространенными формами меланом кожи конечностей // Поволжский онкологический вестник. - 2011. - № 1. - С. 94-95.
Abu-Rustum N.R., Barakat R.R., Levine D.A. Atlas of Procedures in Gynecologic Oncology, Third Edition / Abu-Rustum N.R., Barakat R.R., Levine D.A., USA: CRC Press, 2013. - 472 р.
Alexander H.R., Fraker D.L., Barlett D.L. Isolated limb perfusion for malignant melanoma // Semin. Surg. Oncol. - 1996. - Vol. 12. - P. 416-428.
Baratti D., Kusamura S., Guaglio M., Deraco M. Peritoneal metastases: challenges for the surgeon // Minerva Chir. - 2015. - Vol. 70. - P. 195-215.
Blackmon S.H., Stephens E.H., Correa A.M. et al. Predictors of recurrent pulmonary metastases and survival after pulmonary metastasectomy for colorectal cancer // Ann. Thorac. Surg. - 2012. - Vol. 94. - P. 1802-1809.
Chua T.C., Yan T.D., Smigielski M.E. et al. Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience from a single institution // Ann. Surg. Oncol. - 2009. - Vol. 16. - P. 1903-1911.
El Halabi H., Gushchin V., Francis J. et al. The role of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) in patients with high-grade appendiceal carcinoma and extensive peritoneal carcinomatosis // Ann. Surg. Oncol. - 2012. - Vol. 19. - P. 110-114.
Elias D., Gilly F., Quenet F. et al. Pseudomyxoma peritonei: a French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy // Eur. J. Surg. Oncol. - 2010. - Vol. 36. - P. 456-462.
Grootenboers M.J., Schramel F.M., van Boven W.J. et al. Re-evaluation of toxicity and long-term follow-up of isolated lung perfusion with melphalan in patients with respectable pulmonary metastases: phase I and extentional trial // Ann. Thorac. Surg. - 2007. - Vol. 83. - P. 1235-1236.
Haslinger M.A., Francescutti V., Attwood K. Contemporary analysis of morbidity and outcomes in cytoreduction/ hyperthermic intraperitoneal chemoperfusion // Cancer Med. - 2013. - Vol. 2. - P. 334-342.
Hendriks J.M., Romijn S., Van Putte B. et al. Long-term results of surgical resection of lung metastases // Acta Chir. Belg. - 2001. - Vol. 101. - P. 267-272.
Hengst W.A., Hendriks J.M., Balduyck B. et al. Phase II Multicenter clinical trial of pulmonary metastasectomy and isolated lung perfusion with melphalan in patients with resectable lung metastases // J. Thorac. Oncol. -2014. - Vol. 9. - P. 1547-1553.
Markman M. Regional chemotherapy: clinical research and practice / Markman M., NJ: Humana Press, 1999. - 376 pp.
Mohamed F., Cecil T., Moran B., Sugarbaker P. A new standard of care for the management of peritoneal surface malignancy // Curr. Oncol. - 2011. - Vol. 18. - P. 84-96.
Muller H., Hilger R. Curative and palliative aspects of regional chemotherapy with surgery // Support Care Cancer. - 2003. - Vol. 11. - P. 1-10.
Spiliotis J.D., Rogdakis A., Vaxevanidou A. et al. Morbidity and mortality of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal carcinomatosis // J. B.U.ON. - 2009. - Vol. 14. - P. 259-264.
Sugarbaker P.H. Overview of peritoneal carcinomatosis // Cancerologia. - 2008. - Vol. 3. - P119-124.
Verwaal V.J. Long-term results of cytoreduction and HIPEC followed by systemic chemotherapy // Cancer J. - 2009. - Vol. 15. - P. 212-215.
Ward A., Prokrym K., Pass H. Isolated lung perfusion for pulmonary metastases // Thorac. Surg. Clin. - 2016. -Vol. 26. - P. 55-67.
All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...