How to Cite
Abstract
There were performed researches on morphometric (the nuclear area, perimeter, the maximum and minimum diameters) and densitometric (optical density, integrated optical density) parameters of nuclei of cells on the cytologic smears received from 28 patients with atypical hyperplasia and an initial breast cancer. Significant reduction of measured nuclei parameters was noted among: moderately - and high-grade ductal carcinoma in situ, atypical ductal hyperplasia, lobular carcinoma in situ, an invasive papillary cancer, intraductal papilloma. The lowest value of the measured parameters was noted at love-grade ductal carcinoma in situ and intraductal papillary cancer. It was established that morphometric and densitometric indicators at atypical hyperplasia of an epithelium and an initial breast cancer in some cases overlap each other that is at the bottom of difficulties of differential cytomorphological diagnostics and quite often forces to formulate the cytologic conclusion in the presumable form.References
Волченко H.H., Славнова Е.Н., Гладунова З.Д. и др. Цитоморфологическая характеристика дисплазий молочной железы // Российский онкологический журнал. - 2006. - Т. 1. - С. 21-24.
Шабалова И.П., Джангирова Т.В., Волченко H.H., Пугачев К.К. Цитологический атлас: Диагностика заболеваний молочной железы. - М.-Тверь: ООО «Издательство «Триада», 2005. - 119 с.
Dey P., Ghoshal S., Pattari S.K. Nuclear image morphometry and cytologic grade of breast carcinoma // Anal Quant Cytol Histol. - 2000. - Vol. 22. - N 6. - P. 483-485.
Gomes D.S., Porto S. S., Balabram D., Gobbi H. Interobserver variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast// Diagnostic Pathology. - 2014. - Vol. 9. - P. 121.
al-Kaisi N. The spectrum of the “gray zone” in breast cytology: A review of 186 cases of atypical and suspi cious cytology // Acta Cytol. - 1994. - Vol. 38. - P. 898-908.
Kalhan S., Dubey S., Sharma S. et al. Significance of nuclear morphometry in cytological aspirates of breast masses // J.Cytol. - 2010. - Vol. 27. - N 1. - P. 16-21.
Nagashima T., Suzuki M., Yagata H. et al. Cytomorphometric differentiation of intraductal proliferative breast lesions // Breast Cancer. - 2000. - Vol. 7. - N 1. - P. 43-47.
Norris H.J., Bahr G.F., Mikel U.V. A comparative morphometric and cytophotometric study of intraductal hyperplasia and intraductal carcinoma of the breast // Anal Quant Cytol Histol. - 1988.- Vol. 10. - N 1. - P. 1-9.
Ruiz A., Almenar S., Callaghan R.C., Llombart-Bosch A. Benign, preinvasive and invasive ductal breast lesions. A comparative study with quantitative techniques: morphometry, image- and flow cytometry // Pathol Res Pract. - 1999. - Vol. 195. - N 11. - P. 741-746.
Shabb N. S., Boulos F. I., Abdul-Karim F. W. Indeterminate and Erroneous Fine-Needle aspirates of breast with focus on the ‘true gray zone’: A review // Acta Cytol. - 2013. - Vol. 57. - P. 316-331.
Shabb N.S., Boulos F.I., Chakhachiro Z. et al. Inconclusive or erroneous fine-needle aspirates of breast with adequate and representative material: a cytologic/histologic study // Diagn Cytopathol. - 2014. - Vol. 42. - N 5. - P. 405-415.
Tahlan A., Nijhawan R., Joshi K. Grading of ductal breast carcinoma by cytomorphology and image morphometry with histologic correlation // Anal Quant Cytol Histol. - 2000. - Vol. 22. - N 3. - P. 193-198.
Tse G., Tan P.H., Schmitt F. Fine needle aspiration cytology of the breast. Atlas of cyto-histologic correlates / Springer-Verlag Berlin Heidelberg. - 2013. - 192 p.
All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...