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Abstract
It is necessary to maintain the safety of the cell proteome for the operation and adequate biological response of tumor cells to changing conditions, which is provided by chaperones and ATP-dependent proteases. Molecular chaperones, which include the small heat shock proteins, carry out folding, refolding and misfolding of proteins, support functional activity of intracellular proteins. Proteases, mainly proteasome, degrade abnormal, damaged and fulfilling its function proteins. The review presents modern data on the role of the proteasome and heat shock proteins in malignant tumors as well as the mechanism of interaction of these systems in the cell.References
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