Associativity of microRnA levels in blood serum to quantity and functional activity of haemo - and lymphopoiesis cells in experimental breast cancer
Vol. 62 No. 3 (2016), Articles
Vol. 62 No. 3 (2016)

Associativity of microRnA levels in blood serum to quantity and functional activity of haemo - and lymphopoiesis cells in experimental breast cancer

Articles
https://doi.org/10.37469/0507-3758-2016-62-3-519-524
Published 15.12.2016
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Fundamental and Clinical Immunology
Research Institute of Clinical and Experimental Lymphology
Research Institute of Molecular Biology and Biophysics
Research Institute of Molecular Biology and Biophysics
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Keywords

N - methyl - N- nitrosourea
microRNA
breast cancer
proliferative potential
cytokines

How to Cite

, , , , , , , , , , , & . (2016). Associativity of microRnA levels in blood serum to quantity and functional activity of haemo - and lymphopoiesis cells in experimental breast cancer. Voprosy Onkologii, 62(3), 519–524. https://doi.org/10.37469/0507-3758-2016-62-3-519-524
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Abstract

The work purpose was to reveal an existence of an associativity of the microRNA levels in blood serum to quantitative and functional indices of cells haemo - and lymphopoiesis at the experimental breast cancer induced by N -methyl - N- nitrosourea in the remote period after surgery and carrying out neoadjuvant polychemotherapy. At animals there were investigated levels of microRNA-21, microRNA-221, microRNA-222 and microRNA-429 in serum, also investigated quantitative and functional parameters of cells from bone marrow, from lymph of a chest channel and from spleen. Statistically significant distinctions on the microRNA level in blood serum and an existence of interrelations of microRNA levels with quantitative and functional indices of haemo- and lymphopoiesis cells were revealed.
https://doi.org/10.37469/0507-3758-2016-62-3-519-524
PDF (Русский)

References

Беседнова Н.Н., Федянина Л.Н. Противоопухолевое действие экзогенной дезоксирибонуклеиновой кислоты // Тихоокеанск. мед. журнал. - 2009. - № 3. - С. 12-18.

Hui C., Yujie F., Lijia Y. et al. MicroRNA-34a and microR-NA-21 play roles in the chemopreventive effects of 3,6-di-hydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis // Breast Cancer Research. - 2012. - Vol. 14. - P. 80-91.

Jin L.H., Wei C. Role of microRNAs in the Warburg effect and mitochondrial metabolism in cancer // Asian Pac. J. Cancer Prev. - 2014. - Vol. 15. - P 7015-7019.

Juhasz K., Gombos K., Gocze K. et al. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice // J. Environ. Occup. Sci. - 2012. - Vol. 1. - P. 77-82.

Li Z., Branham W.S., Dial S.L. et al. Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea // BMC Genomics. - 2010. - Vol. 11. - P. 609- 622.

Shah M.Y., Calin G.A. MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer // Genome Medicine. - 2011. - Vol. 3. - P 56-59.

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