Vol. 70 No. 3 (2024), CLINICAL CASES

Vol. 70 No. 3 (2024)

Uterine Tumors Histologically Resembling Ovarian Sex Cord Neoplasms: Literature Review and Discussion of Patient Management

CLINICAL CASES

https://doi.org/10.37469/0507-3758-2024-70-3-569-578

Published 04.07.2024

Nataliia Aleksandrovna Babaeva⁺⁻
Apollon Irodionovich Karseladze⁺⁻
Viktoriia Sergeevna Surkova⁺⁻
Olga Vladimirovna Bourmenskaya⁺⁻
Natalia Anatolievna Redkina⁺⁻
Aleksandra Vyacheslavovna Asaturova⁺⁻
Olga Ivanovna Aleshikova⁺⁻
Levon Andreevich Ashrafyan⁺⁻

Nataliia Aleksandrovna Babaeva

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0002-4654-9512

Apollon Irodionovich Karseladze

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0001-9660-923X

Viktoriia Sergeevna Surkova

Federal State Budgetary Institution "Scientific Medical Research Center of Radiology" of the Ministry of Health of Russia

https://orcid.org/0000-0002-2674-0416

Olga Vladimirovna Bourmenskaya

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0003-2842-3980

Natalia Anatolievna Redkina

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0003-3056-6067

Aleksandra Vyacheslavovna Asaturova

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0001-8739-5209

Olga Ivanovna Aleshikova

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0002-2957-3940

Levon Andreevich Ashrafyan

NATIONAL MEDICAL RESEARCH CENTER FOR OBSTETRICS, GYNECOLOGY AND PERINATOLOGY NAMED AFTER ACADEMICIAN V.I.KULAKOV

https://orcid.org/0000-0001-6396-4948

pdf (Русский)

Keywords

Uterine tumor histologically similar to ovarian sex cord tumors
uterine tumor resembling ovarian sex cord tumors (UTROSCT)
gene JAZF1-JJAZ1 (JAZF1–SUZ12)
endometrial stromal tumors
endometrial stromal tumor with sex-cord-like elements (ESTSCLE)

How to Cite

Babaeva, N. A., Karseladze, A. I., Surkova, V. S., Bourmenskaya, O. V., Redkina, N. A., Asaturova, A. V., Aleshikova, O. I., & Ashrafyan, L. A. (2024). Uterine Tumors Histologically Resembling Ovarian Sex Cord Neoplasms: Literature Review and Discussion of Patient Management. Voprosy Onkologii, 70(3), 569–578. https://doi.org/10.37469/0507-3758-2024-70-3-569-578

Abstract

Uterine tumors histologically similar to ovarian sex cord tumors represent a rare type of neoplasm classified into two groups: endometrial stromal tumor with sex-cord-like elements (ESTSCLE, type I) and uterine tumor resembling ovarian sex cord tumor (UTROSCT, type II), with different clinical features, immunohistochemical characteristics and prognosis. Most endometrial stromal tumors with foci of sex-cord-like elements have genetic fusions, the most common of which is JAZF1-SUZ12. Due to the small number of observations, no clinical guidelines have been developed for their treatment. For women with UTROSCOT who wish to preserve their fertility, conservative treatment options may be considered after careful evaluation of the surgical specimen. If the patient has the ESTSCLE variant, which is combined with endometrial stromal sarcoma, radical surgical treatment is required.

https://doi.org/10.37469/0507-3758-2024-70-3-569-578

pdf (Русский)

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