Abstract
Introduction. Skin-sparing mastectomy with preservation of the nipple-areolar complex (NAC) yields favorable aesthetic outcomes. However, in patients with large, ptotic breasts, skin-sparing mastectomy is associated with an elevated risk of complications, including NAC and skin flap necrosis.
Aim. To analyze the complication rates associated with skin-sparing mastectomy followed by immediate implant-based reconstruction and NAC transfer on a dermal pedicle.
Materials and Methods. A retrospective analysis of complications was performed in breast cancer (BC) patients who underwent skin-sparing mastectomy with immediate implant reconstruction and NAC transfer on a dermal pedicle.
Results. 70 reconstructions were performed in 49 patients. Univariate analysis identified a body mass index (BMI) ≥ 35 kg/m² and the use of a superior dermal pedicle as significant risk factors for total NAC necrosis (p = 0.05 and p = 0.001, respectively).
Conclusion. Utilization of a superomedial dermal pedicle reduces the incidence of NAC necrosis to 11 %, compared to 48 % with a superior dermal pedicle. Due to the high risk of total NAC necrosis, this procedure is not recommended for patients with a BMI ≥ 35 kg/m².
References
Mota B.S., Riera R., Ricci M.D., et al. Nipple- and areola-sparing mastectomy for the treatment of breast cancer. Cochrane Database Syst Rev. 2016; 11: CD008932.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5868722/.
Catanuto G., Rocco N., Nava M.B. Surgical decision making in conservative mastectomies. Gland Surg. 2016; 5: 69-74.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC4716861/.
Chirappapha P., Petit J.Y., Rietjens M., et al. Nipple sparing mastectomy: does breast morphological factor related to necrotic complications? Plast Reconstr Surg Glob Open. 2014; 2: e99.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174220/.
Bostwick J. Total mastectomy with breast, skin and volume reduction using an inverted “T” incision. In: Plastic and Reconstructive Surgery. St. Louis: Quality Medical Publishing; 1990: 1048-1054.-URL: https://www.scienceopen.com/book?vid=c2c1f17c-dd88-47cf-97fb-7c8911699f51.
Della Rovere G.Q., Nava M., Bonomi R., et al. Skin-reducing mastectomy with breast reconstruction and sub-pectoral implants. J Plast Reconstr Aesthet Surg. 2008; 61: 1303-1308.-URL: https://www.jprasurg.com/article/S1748-6815(07)00365-8/abstract.
Nava M.B., Cortinovis U., Ottolenghi J., et al. Skin-reducing mastectomy. Plast Reconstr Surg. 2006; 118: 603-610; discussion 611-613.-URL: https://journals.lww.com/plasreconsurg/fulltext/2006/09010/skin_reducing_mastectomy.5.aspx.
Regnault P. Breast ptosis. Definition and treatment. Clin Plast Surg. 1976; 3: 193-203.-URL: https://pubmed.ncbi.nlm.nih.gov/1261176/.
Rancati A.O., Angrigiani C.H., Hammond D.C., et al. Direct to implant reconstruction in nipple sparing mastectomy: patient selection by preoperative digital mammogram. Plast Reconstr Surg Glob Open. 2017; 5: e1369.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5505842/.
Pagliara D., Schiavone L., Garganese G., et al. Predicting mastectomy skin flap necrosis: a systematic review of preoperative and intraoperative assessment techniques. Clin Breast Cancer. 2023; 23: 249-254.-URL: https://pubmed.ncbi.nlm.nih.gov/36725477/.
Nava M.B., Ottolenghi J., Pennati A., et al. Skin/nipple sparing mastectomies and implant-based breast reconstruction in patients with large and ptotic breast: oncological and reconstructive results. Breast. 2012; 21: 267-271.-URL: https://www.thebreastonline.com/article/S0960-9776(11)00007-5/fulltext.
Mundy L.R., Homa K., Klassen A.F., et al. Breast cancer and reconstruction: normative data for interpreting the BREAST-Q. Plast Reconstr Surg. 2017; 139: 1046e-1055e.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5713639/.
Carlson G.W., Chu C.K., Moyer H.R., et al. Predictors of nipple ischemia after nipple sparing mastectomy. Breast J. 2014; 20: 69-73.-URL: https://onlinelibrary.wiley.com/doi/10.1111/tbj.12208.
Yazar S., Bengur F.B., Altinkaya A., et al. Nipple-sparing mastectomy and immediate implant-based reconstruction with or without skin reduction in patients with large ptotic breasts: a case-matched analysis. Aesthetic Plast Surg. 2021; 45(3): 956-967.-DOI: doi.org/10.1007/s00266-020-02000-w.
Hudson P.A., Skoll P.J. Complete one stage, immediate breast reconstructions with prosthetic material in patients with large or ptotic breasts. Plast Reconstr Surg. 2002; 110: 487.-URL: https://pubmed.ncbi.nlm.nih.gov/12142665/.
Hammond D.C., Capraro P.A., Arnold J.F., et al. Use of a skin-sparing reduction pattern to create a combination skin-muscle flap pocket in immediate breast reconstruction. Plast Reconstr Surg. 2002; 110: 206.-URL: https://pubmed.ncbi.nlm.nih.gov/12087255/.
Duet M., Pestana I.A. Outcomes of nipple-sparing mastectomy in the ptotic and non-ptotic breast with staged-immediate reconstruction timing and pre-pectoral, direct-to-implant technique. Cureus. 2023; 15(7): e42363.-DOI: doi.org/10.7759/cureus.42363.
Tondu T., Thiessen F., Hubens G., et al. Delayed two-stage nipple sparing mastectomy and simultaneous expander-to-implant reconstruction of the large and ptotic breast. Gland Surg. 2022; 11(3): 524-534.-DOI: doi.org/10.21037/gs-21-734.
Rapisarda I.F., Cook L.J., Gilani S.N.S., Bonomi R. Nipple-sparing skin-reducing mastectomy for women with large and ptotic breasts: a 6-year, single-centre experience with the bipedicled dermal flap approach. Indian J Surg. 2021; 83: 446-453.-URL: https://link.springer.com/article/10.1007/s12262-021-02725-1.
Cogliandro A., Salzillo R., De Bernardis R., et al. Prepectoral versus subpectoral direct-to-implant breast reconstruction: evaluation of patient’s quality of life and satisfaction with BREAST-Q. Aesthetic Plast Surg. 2023; 47: 1291-1299.-URL: https://pubmed.ncbi.nlm.nih.gov/36944866/.
Kroll S.S., Khoo A., Singletary S.E., et al. Local recurrence risk after skin-sparing and conventional mastectomy: a 6-year follow-up. Plast Reconstr Surg. 1999; 104: 421.-URL: https://pubmed.ncbi.nlm.nih.gov/10654685/.
Slavin S.A., Schnitt S.J., Goldwyn R.M., et al. Skin-sparing mastectomy and immediate reconstruction: oncologic risks and aesthetic results in patients with early-stage breast cancer. Plast Reconstr Surg. 1998; 102: 49.-URL: https://pubmed.ncbi.nlm.nih.gov/9655407/.
Rivadeneira D.E., Simmons R.M., Osborne M.P., et al. Skin-sparing mastectomy with immediate breast reconstruction: a critical analysis of local recurrence. Cancer J. 2000; 6: 331.-URL: https://pubmed.ncbi.nlm.nih.gov/11079173/.
Simmons R.M., Fish S.K., Osborne M.P., et al. Local and distant recurrence rates in skin-sparing mastectomies compared with non-skin-sparing mastectomies. Ann Surg Oncol. 1999; 6: 676.-URL: https://pubmed.ncbi.nlm.nih.gov/10560854/.
Medina-Franco H., Vasconez L.O., Urist M.M., et al. Factors associated with local recurrence after skin-sparing mastectomy and immediate breast reconstruction for invasive breast cancer. Ann Surg. 2002; 235: 814.-URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC1422510/.
Kobraei E.M., Nimtz J., Wong L., et al. Risk factors for adverse outcome following skin-sparing mastectomy and immediate prosthetic reconstruction. Plast Reconstr Surg. 2012; 129: 234e-241e.-DOI: doi.org/10.1097/PRS.0b013e31823aec7f.
Driessen C., Arnardottir T.H., Lorenzo A.R., Mani M.R. How should indocyanine green dye angiography be assessed to best predict mastectomy skin flap necrosis? A systematic review. J Plast Reconstr Aesthet Surg. 2020; 73: 1031-1042.-DOI: doi.org/10.1016/j.bjps.2020.02.025.

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