Chemotherapy and intraoperative radiation therapy for operable stage III non-small cell lung cancer
Vol. 62 No. 4 (2016), Articles
Vol. 62 No. 4 (2016)

Chemotherapy and intraoperative radiation therapy for operable stage III non-small cell lung cancer

Articles
https://doi.org/10.37469/0507-3758-2016-62-4-450-456
Published 15.12.2016
Tomsk Research Institute of Oncology
Tomsk Research Institute of Oncology; Siberian State Medical University
Tomsk Research Institute of Oncology; Siberian State Medical University
PDF (Русский)

Keywords

non-small cell lung cancer
chemotherapy
surgical treatment
intraoperative radiation therapy
radiosensibilization

How to Cite

, , & . (2016). Chemotherapy and intraoperative radiation therapy for operable stage III non-small cell lung cancer. Voprosy Onkologii, 62(4), 450–456. https://doi.org/10.37469/0507-3758-2016-62-4-450-456
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Abstract

The study was undertaken to evaluate results of combined modality treatment including intraoperative radiation therapy (IORT) in 202 patients with stage III non-small cell lung cancer. The 5-year disease-free and overall survival rates in patients who underwent 15 Gy IORT were 18. 7% and 29. 2%, respectively. The overall response rate to preoperative chemotherapy with paclitaxel/carboplatin was 43. 7%, treatment was well tolerated. Preoperative chemotherapy with paclitaxel/ carboplatin in combination with 15 Gy IORT led to a significant increase in the 5-year disease-free and overall survival rates to 31. 4% and 39. 2%, respectively (p<0. 05). The 5-year disease-free and overall survival rates were respectively 32. 6% and 40. 8% in patients who received additional administration of cisplatin combined with 10 Gy IORT. Radiosensibilization with cisplatin in patients treated with 15 Gy IORT increased the 5-year disease-free and overall survival rates to 41. 7% and 47. 9%, respectively (p<0. 05).
https://doi.org/10.37469/0507-3758-2016-62-4-450-456
PDF (Русский)

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