Blood DNA radiosentivity as a predictive bindex of radiochemical treatment efficacy in cervical cancer patients
##article.numberofdownloads## 65
##article.numberofviews## 59
PDF (Русский)

Keywords

cervical cancer
radiochemical treatment
blood DNA
efficacy treatment prediction

How to Cite

, , , , , & . (2016). Blood DNA radiosentivity as a predictive bindex of radiochemical treatment efficacy in cervical cancer patients. Voprosy Onkologii, 62(4), 465–470. https://doi.org/10.37469/0507-3758-2016-62-4-465-470

Abstract

Study of cervical cancer patients with I-III stage was performed with biomarker determination of the blood DNA radiosensitivity ex vivo. The biochemical index was measured before treatment start during 4 hours by use fluorescent dye. The relationship between changes of these index levels and volume tumor reductions after radiochemical treatment evidenced that blood DNA radiosensitivity was enabled to predict an outcome of the cervical cancer patient treatment earlier than the assessment of therapy efficacy by help of ultrasound measurements.
https://doi.org/10.37469/0507-3758-2016-62-4-465-470
##article.numberofdownloads## 65
##article.numberofviews## 59
PDF (Русский)

References

Иванов С.Д. Прогнозирование эффективности лучевой терапии при комбинированном лечении онкологических больных // Вопр. онкол. - 2008. - Т. 54. - № 4. - С. 483-489.

Иванов С.Д., Корытова Л.И. Персонализация лечения опухоленосителей путём предикции эффективности лучевой и химиолучевой терапии на основаНИИ радиочувствительности ДНК крови // Радиац. биология. Радиоэкология. - 2014. - Т. 54. - № 5. - С. 453-465.

Иванов С.Д., Ямшанов В.А., Маслюкова Е.А. Способ определения показаний к проведению органосохраняющего лечения больных раком мочевого пузыря // Пат. изобр. № 2319963.-С. 1-5.-Опубл. 20.03.2008. Бюл. № 8.

Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2014 годую - М.: МНИОИ им. П.А. Герцена, филиал ФГБУ «НМИРЦ» Минздрава России. - 2015. - 236 с.

Минько Б.А., Холин А.В. Ультразвуковая диагностика рака шейки матки. В кн. Ультразвуковые исследования в диагностике и лечении онкоурологических и онкогинекологических заболеваний. - СПб: Изд-во СЗГМУ им. И.И. Мечникова.- 2013. - С.107-129.

Рева И.В., Рева Г.В., Ямамото Т., Толмачёв В.Е. Механизмы канцерогенеза в коже человека на фоне папилломавирусной инфекции // Бюл. эксперим. биол.-2014. - Т. 157. - № 6. -С. 648-654.

Bermudez R.S., Huang K., Hsu I.-C. Рак шейки матки. / В кн. Хансен Э.К., Роач III М. Лучевая терапия в онкологии. Пер. с англ. п /ред. А.В.Черниченко.- М.: ГЭОТАР - Медиа. - 2014. -С. 676-696.

den Boon J.A., Pyeon D., Wang S.S. et al. Molecular transition from papillomavirus infecrion to cervical precancer and cancer: Role of stromal estrogen receptor signaling // Proc. Natl. Acad. Sci. USA. - 2015. - Vol. 112. - No 27. - P. E3255-E3264.

Chung S.H., Lambert P.F. Prevention and treatment of cervical cancer in mice using estrogen receptor antagonosts // Proc. Natl. Acad. Sci. USA. - 2009. - Vol. 106. - No 46.- P. 19467-19472.

Eschrich S.A., Fulp W.J., Pawitan Y et al. Validation of a radiosensitivity molecular signature in breast cancer // Clin. Cancer Res. - 2012. - Vol. 18. - No 18. - P. 5134-5143.

Friedrich M., Mink D., Villena-Heinsen C. et al. Tamoxifen and proliferation of vaginal and cervical epithelium in postmenopausal women wiyh breast cancer // Eur. J. Gynecol. Reprod. Biol. -1998. - Vol. 80. - No 2. - P 221-225.

Gabelova A., Farkasova T., Gurska S. et al. Radiosensitivity of peripheral blood lymphocytes from healthy donors and cervical cancer patients; the correspondence of in vitro data with the clinical outcome // Neoplasma. - 2008. - Vol. 55.- No 2.- P. 182-191.

zur Hausen H. Papillomavirus in the causation of human cancers - A brief historical account // Virology. - 2009. - Vol. 384. - No 2. - P. 260-265.

Landoni F., Maneo A., Colombo A. et al. Randomised study of radical surgery versus radiotherapy for stage IB-IIA cervical cancer // Lancet. - 1977. - Vol. 350. - P.535-540.

Lopez-Lazaro M. The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? // Anticancer Agents Med. Chem. - 2008. - Vol. 8. - P 305-312.

Luhn P, Walker J., Schiffman M. et al. The role of co-factors in the progression from human papillomavirus infection to cervical cancer // Gynecol. Oncol. - 2013. - Vol. 128. - No 2. - P. 265-270.

Nakamura M., Bodily J.M., Begin M. et al. Hypoxia-specific stabilization of HIF-1alpha by human papillomavirus // Virology. - 2009. - Vol. 387. - No 2. - P 442-448.

Petignat P., Roy M. Diagnosis and management of cervical cancer // B.M.J. - 2007. - Vol. 335. -P 765-768.

Rose PG. Chemoradiotherapy for cervical cancer // Eur. J. Cancer. - 2002. - Vol. 38. - P. 270-278.

Tavares-Murta B.M., Mendonca M.A.O., Duarte N.L. et al. Systemic leukocyte alterations are associated with invasive uterine cervical cancer // Int. J. Gynecol. Cancer. - 2010. - Vol. 20. - No 7. - P. 1154-1159.

West C.M., Davidson S.E., Elzan S.A. et al. Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix // Int.J.Radiat. Oncol. Biol. Phys. - 2001. - Vol. 51. - No 1. - P. 10-15.

Widel M., Jedrus S., Lukaszczyk B. et al. Radiation-induced micronucleus frequency in peripheral blood lymphocytes is correlated with normal tissue damage in patients with cervical carcinoma undergoing radiotherapy // Radiat. res. - 2003. - Vol. 159. - P. 713-721.

World Health Organization. Human papillomavirus and cervical cancer. Fact Sheet. - 2015. - No 380.

Zhao C., Matthews J., Tujague M. et al. Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells // Cancer Res. - 2007. - Vol. 67. - No 8. - P. 3955-3962.

All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...