Phenotypic and functional characteristics of dendritic cells and contents of suppressor cell populations in peripheral blood of breast cancer patients
Vol. 62 No. 4 (2016), Articles
Vol. 62 No. 4 (2016)

Phenotypic and functional characteristics of dendritic cells and contents of suppressor cell populations in peripheral blood of breast cancer patients

Articles
https://doi.org/10.37469/0507-3758-2016-62-4-519-523
Published 15.12.2016
Research Institute of Fundamental and Clinical Immunology
Research Institute of Fundamental and Clinical Immunology
Research Institute of Fundamental and Clinical Immunology
Research Institute of Fundamental and Clinical Immunology
Research Institute of Fundamental and Clinical Immunology
City Clinical Hospital № 1 Novosibirsk
Research Institute of Fundamental and Clinical Immunology
PDF (Русский)

Keywords

breast cancer
dendritic cell
flow cytometry

How to Cite

, , , , , , & . (2016). Phenotypic and functional characteristics of dendritic cells and contents of suppressor cell populations in peripheral blood of breast cancer patients. Voprosy Onkologii, 62(4), 519–523. https://doi.org/10.37469/0507-3758-2016-62-4-519-523
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Abstract

The progression or the appearance of distant metastases in breast cancer (BC) is influenced by a variety of antitumor immune response suppression mechanisms. In this paper we study circulating dendritic cells (DC) and the suppressor cell populations in peripheral blood of breast cancer patients. The study of phenotypic and functional properties of DCs was performed in the samples of intact and TLR-stimulated whole blood from breast cancer patients and healthy women by multicolor flow cytometry. To determine the suppressor cell population among lymphocytes multicolor panel comprising markers CD 4, CD 25, CD 127, FoxP3 was used. It is showed that the formation of secondary foci of tumor growth in patients was accompanied by disturbances of the functional activity plasmocytoid DC and accumulation of cells with immunosuppressive functions.
https://doi.org/10.37469/0507-3758-2016-62-4-519-523
PDF (Русский)

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