A COMPARATIVE STUDY OF MIELOPROTECTION EFFECT OF DICARBAMINE AND LEUCOSTIM IN CONDITIONS OF EXPERIMENTAL POST-RADIATION BONE MARROW SYNDROME

Abstract

There was studied the effect of dicarbamine and leucostim on myelopoiesis in conditions of experimental post-radiation bone marrow syndrome. Dicarbamine in different modes of administration and doses provided a high level of protection of proliferating hematopoietic precursors in the early period after radiation, which was reflected in a statistically significant decrease in the depth and duration of post-radiation deficit of cells that made up the granulocyte, lymphocyte, megakaryocyte and erythroid series. The greatest effect of the drug appeared at a dose of 4 mg/kg (course of health-prophylactic administration) and a dose of 15 mg/kg (medical doubled administration). In the bone marrow of experimental animals leucostim prevented development of post-radiation deficit of granulocytes and lymphocytes to a lesser extent, than dicarbamine, and it was effective in erythroid and megakaryocyte series.