Abstract
PET with 18F-FDG was administered to 46 patients with different morphological types of neuroendocrine tumors. The method appeared to be highly sensitive in the diagnosis of atypical carcinoids as well as neuroendocrine large-cell lung cancer and small-cell lung cancer. At the same time its imaging capabilities in the detection of typical carcinoids were limited. The sensitivity of PET in these patients was 66.7%. However, the absence of 18F-FDG hyperfixation in typical carcinoids had strong evidence in favor of conditional benign process.References
Brown R.S., Leung J.Y., Kison P.V. et al. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer // J. Nucl. Med. — 1999 — Vol. 40 — P. 556-565.
Daniels C.E., Lowe V.J., Aubry M.C. et al. The utility of fluorodeoxyglucose positron emission tomography in the evaluation of carcinoid tumors presenting as pulmonary nodules // Chest. — 2007 — Vol. 131. — P. 255-260.
Erasmus J.J., Macapinlac H.A. Low-sensitivity FDG-PET studies: less common lung neoplasms // Semin Nucl Med — 2012 — Vol. 42. — P. 255-260.
Geus-Oei L.F., Krieken J.H., Aliredjo R.P. et al. Biological correlates of FDG uptake in non-small cell lung cancer. // Lung Cancer — 2007 — Vol.55. — P. 79-87.
Krüger S., Buck A.K., Blumstein N.M. et al. Use of integrated FDG PET/CT imaging in pulmonary carcinoid tumours // J. Intern. Med. — 2006 — Vol. 260. — P. 545-550.
Mimae T., Yamashita M., Maeda A. et al. Large cell neuroendocrine carcinoma of the lung // Kyobu Geka — 2009 — Vol. 62. — P. 442-445.
Oberg K., Hellman P., Kwekkeboom D. Neuroendocrine bronchial and thymic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up // Ann. Oncol. — 2010 — Suppl 5. — P. 220-222.
Severi S., Nanni O., Bodei L et al. Role of (18)FDG PET/CT in patients treated with (177)Lu-DOTATATE for advanced differentiated neuroendocrine tumours // Europ J Nucl Med Mol Imaging — 2013 — Vol. 40. — P. 881-888.
Song Y.S., Lee W.W., Chung J.H. et al. Correlation between FDG uptake and glucose transporter type 1 expression in neuroendocrine tumors of the lung // Lung Cancer — 2008 — Vol. 61. — P. 54-60.
All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...