A Clinical Case of Successful Treatment of HER2-Low Disseminated Breast Cancer with Trastuzumab Deruxtecan

Keywords

argeted anti-HER2 therapy
trastuzumab
Trastuzumab deruxtecan
hormone-positive metastatic breast cancer
HER2-Low

How to Cite

Panferova, E., Tepikina, G., Baryshnikov, E., Panferova, E., Murzin, A., Prokhorenko, A., Chupakhin, I., & Klemesheva, E. (2023). A Clinical Case of Successful Treatment of HER2-Low Disseminated Breast Cancer with Trastuzumab Deruxtecan. Voprosy Onkologii, 69(4), 757–760. https://doi.org/10.37469/0507-3758-2023-69-4-757-760

Abstract

Trastuzumab-based anti-HER2 therapy is the standard treatment for patients with HER2-positive tumors. Implementation of targeted therapy has significantly improved the prognosis and quality of life for patients with HER2-positive breast cancer (HER2+).

In this clinical case, we present the first experience in the Irkutsk region of effectively treating a patient with progressive disseminated hormone receptor-positive breast cancer with low HER2 expression (HER2-Low) using the drug trastuzumab deruxtecan. The patient had nearly exhausted all possibilities of anti-tumor drug treatment. Similar efficacy of trastuzumab deruxtecan has been demonstrated in a study called DESTINY-Breast04 (NCT03734029) involving a similar group of patients.

https://doi.org/10.37469/0507-3758-2023-69-4-757-760

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