Safety of Amino Acid Solutions for Parenteral Nutrition in Abdominal Oncosurgery

Abstract

Introduction. The safety and efficacy of parenteral nutrition are of particular importance in oncosurgical patients.

Aim. To evaluate the metabolic and organ safety of amino acid solutions for parenteral nutrition with different amino acid profiles and with or without sorbitol, as part of a standardized combination postoperative nutritional support regimen in patients undergoing abdominal oncologic surgery.

Materials and Methods. A prospective, randomized, multicenter safety study of early parenteral administration of amino acid solutions was conducted in 120 patients aged 18–80 years with stage I–III gastrointestinal tumors. Patients were randomly assigned to two groups: one receiving standard amino acid solutions and the other receiving solutions with added sorbitol. Both regimens included 10 mL/kg of amino acid solution per day for 5 days, combined with a 10 % dextrose solution, alongside early enteral nutrition. Metabolic parameters (glucose, lactate, malondialdehyde, amino acid profile), water and electrolyte balance (K⁺, Na⁺, Cl⁻, Ca²⁺, fluid balance), and biochemical parameters reflecting organ function and nutritional status were recorded.

Results. Throughout all stages of the study, no cases of exceeding the reference intervals for the parameters studied were recorded. The use of an amino acid solution with the addition of sorbitol did not lead to changes in metabolic parameters or hepatorenal dysfunction. Both study preparations demonstrated a similarly high safety profile.

Conclusion. Following gastrointestinal surgery, amino acid solutions provide an equally high level of safety with respect to metabolism, water and electrolyte balance, and organ dysfunction in oncosurgical patients.