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Abstract
In this mini-review the basic evidence about anticancer properties of ursolic acid (UA), the compound belonging to the class of triterpenoids, is given. Beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, UA (as well as some other related and not related compounds) is capable to induce PTEN (a tumor suppressor mutation of which is rather often discovered in human tumors including endometrial cancer type I) and amount/activity of brown fat. The latter action may explain obesity-preventing capacity of UA that also may lead to an additional antiblastomogenic effect.References
Барышников А.Ю., О-Жи-Хо Е.А. Растительные терпеноиды как возможные противоопухолевые агенты // Росс. биотерап. журнал. — 2010. — N 1 — С. 3-8.
Берштейн Л.М. Гетерогенность ожиренияи рак: потенциальная роль бурой жировой ткани // Вопр. онкол. — 2012. — Т.58(4). — С. 464-472.
Беспалов В.Г. Питаниеи рак. Диетическая профилактика онкологических заболеваний. — М., 2008. — 176 с.
Бохман Я.В. Руководство по гинекологической онкологии. Л.: Медицина, 1989,463с.
Шавва А.Г., Антимонова О.И., Морозкина С. Н. Некоторые биологические свойства урсоловой кислоты // Росс. биотерап. журнал. — 2008. -N 2. -С. 65-68.
Andersson D., Cheng Y., Duan R.D. Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. // J Cancer Res Clin Oncol. 2008. — 134. — P. 101-107.
Bansal N., Yendluri V., Wenham R.M. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies // Cancer Control. — 2009. — Vol. 16. — P. 8-13.
Bellows C.F., Zhang Y., Chen J. et al. Circulation of progenitor cells in obese and lean colorectal cancer patients // Cancer Epidemiol Biomarkers Prev. 2011. — Vol. 20(11). — P. 2461-2468.
Bishayee A., Ahmed S., Brankov N., Perloff M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer // Front. Biosci. 2011. — Vol. 16. — P. 980-996.
Cardenas C., Quesada A.R., Medina M.A. Effects of ursolic acid on different steps of the angiogenic process // Biochem. Biophys. Res. Commun. -2004. — Vol. 320. — P. 402-408.
Chang H.P., Wang M.L., Chan M.H. et al. Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice // Nutrition. 2011. — Vol. 27. — P. 463 -470.
Fujiwara K., Mori K., Kaneko Y.S. et al. Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharid // Biochim Biophys Acta. -2004. — Vol. 1670. — P. 181-198.
Gnoatto S.C., Dassonville-Klimpt A., Da Nascimento S. et al. Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition // Eur. J. Med. Chem. 2008. — Vol. 43. — P1865-1877.
Hecht J.L., Mutter G.L. Molecular and pathologic aspects of endometrial carcinogenesis // J Clin Oncol. — 2006. — Vol. 24. P4783-4791.
Hou R., Zhang J., Yin T. Et al. Upregulation of PTEN by peroxynitrite and IFN-gamma contributes to cytokine-induced apoptosis in pancreatic beta-cells // Apoptosis. 2010. — Vol. 15. — P. 877-886.
Hsu Y.L., Kuo P.L., Lin C.C. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells // Life Sci. — 2004. — Vol. 75. — P. 2303-2316.
Huang C.Y., Lin C.Y., Tsai C.W., Yin M.C. Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines // Toxicol In Vitro. 2011. — Vol. 25. — P. 1274-1280.
Jayaprakasam B., Olson L.K., Schutzki R.E. et al. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins andursolic acid in Cornelian cherry (Cornus mas) // J Agric Food Chem. -2006. — Vol. 54. — P. 243-248.
Kondo M., MacKinnon S.L., Craft C.C. et al. Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells // J. Sci. Food Agric. 2011. — Vol. 91(5). P. 789-796.
Kuttan G., Pratheeshkumar P., Manu K.A., Kuttan R. Inhibition of tumor progression by naturally occurring terpenoids // Pharm Biol. 2011. — Vol. 49. — P. 995-1007.
Kwon S.H., Park H.Y., Kim J.Y et al. Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells // Bioorg. Med. Chem. Lett. — 2010. — Vol. 20. — P. 6435-6438.
Kunkel S.D., Elmore C.J., Bongers K.S. et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease // PLoS One. 2012. — Vol. 7. — e39332.
Laszczyk, M. Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy // Planta Medica. 2009. — Vol. 75. — P. 1549-1560.
Liby K.T.,Yore M.M., Sporn M.B. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer // Nat. Rev. Cancer. 2007. — Vol. 7. — P. 357-369.
Liu W., Tan X., Shu L. et al. Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer // Molecules. 2012. — Vol. 17. — P. 9104-9115.
Miller B.T., Ueta C.B., Lau V. et al. Statins and downstream inhibitors of the isoprenylation pathway increase type 2 iodothyronine deiodinase activity // Endocrinology. 2012. — Vol. 153. P. 4039-4048.
Miraglia E., Högberg J., Stenius U. Statins exhibit anticancer effects through modifications of the pAkt signaling pathway // Int J Oncol. — 2012. — Vol. 40. — P. 867-875.
Novotny L., Vachalkova A., Biggs D. Ursolic acid: an antitumorigenic and chemopreventive activity // Neoplasma. 2001. — Vol. 48. — P. 241-246.
Numata A., Yang P., Takahashi C. et al. Cytotoxic triterpenes froma Chinese medicine, Goreishi // Chem Pharm Bull (Tokyo). — 1989. — Vol. 37. — P. 648-651.
Ortega-Molina A., Efeyan A., Lopez-Guadamillas E. et al. PTEN positively regulates brown adipose function, energy expenditure, and longevity // Cell Metab. 2012. — Vol. 15. — P. 382-394.
Qi M., Anderson A.E., Chen D.Z. et al. Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo // Mol Med. 2005. — Vol. 11. — P. 59-63.
Rao V.S., de Melo C.L., Queiroz M.G. et al. Ursolic acid,a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice feda high-fat diet // J Med Food. 2011. — Vol. 14. — P. 1375-1382.
Shanmugam M.K., Rajendran P., Li F. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice // J. Mol. Med (Berl). 2011. — Vol. 89. — P. 713-727.
Shao J.W., Dai Y.C., Xue J.P et al. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives // Eur. J. Med. Chem. 2011. — Vol. 46. — P. 2652-2661.
Shin S.W., Kim S.Y., Park J.W. Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells // Biochim. Biophys. Acta. 2012. — Vol. 1823. — P. 451-457.
Singletary K., MacDonald C., Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a] anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation // Cancer Lett. 1996. — Vol. 104. — P. 43-48.
Tin-Wa M., Farnsworth N.R., Fong H.H., Trojanek J. Catharanthus alkaloids. XXV Isolation of leurosine and ursolic acid from C. pusillus // Lloydia. 1970. — Vol. 33. — P. 261-263.
Tokuda H., Ohigashi H., Koshimizu K., Ito Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate // Cancer Lett. -1986. — Vol. 33. — P. 279-285.
Townsend K.L., Tseng Y.H. Brown adipose tissue. Recent insights into development, metabolic function and therapeutic potential // Adipocyte. — 2012. — Vol. 1. — P. 13-24.
Wang L., Wang G.L., Liu J.H. et al. [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ] // Zhong Xi Yi Jie He Xue Bao. 2012. — Vol. 10. — P. 793-799. [Article in Chinese] PMID: 22805086
Wu B., Wang X., Chi Z.F. et al. Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway // Arch Pharm Res. — 2012. — Vol. 35. — P. 543-548.
Zheng Q.Y., Jin F.S., Yao C. et al. Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells // Biochem Biophys Res Commun. 2012. — Vol. 419. — P. 741-747.
Yoon H., Liu R.H. Effect of 2alpha-hydroxyursolic acid on NF-kappaB activation induced by TNF-alpha in human breast cancer MCF-7 cells // J. Agric. Food Chem. 2008. — Vol. 56. — P. 8412-8417.
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