Polyneoplasia in gastric cancer patients: patterns of development, the results of treatment
Vol. 58 No. 6 (2012), Articles
Vol. 58 No. 6 (2012)

Polyneoplasia in gastric cancer patients: patterns of development, the results of treatment

Articles
https://doi.org/10.37469/0507-3758-2012-58-6-754-761
Published 15.12.2012
Medical Radiological Scientific Center
Medical Radiological Scientific Center
Medical Radiological Scientific Center

Abstract

There were analyzed patterns of polyneoplasia development in radically operated gastric cancer patients. The second tumors were revealed in 99 of 1255 patients (7,9%) as soon as patients with early gastric cancer manifested primary-multiple malignant tumors almost two times more (15,4%). Among second tumors there were predominantly tumors of the colon, urinogenital system, head and neck and also lymphoproliferative diseases. Along with tumors prior to the diagnosis “gastric cancer” there were met mostly lymphoproliferative diseases and breast cancer; of synchronous—cancer of the colon and bladder; among exposed after treatment of gastric cancer—cancer of the colon, pancreas, and skin. Radical surgery because of the second tumor was provided to 77,6% patients, palliative surgery—to 12,6%. In the treatment of second tumors there were most commonly used surgical technique—in 40 (39%) patients, radiotherapy ± chemotherapy—in 27 (26%), the combined method (surgery+radiotherapy/chemotherapy)—in 22 (21%). Second tumors (both synchronous and metachronous) were the main cause of death of patients. Thus, the occurrence of a second tumor in patients with gastric cancer is constantly increasing the frequency of the event, with the possibility of early detection and curative treatment of synchronous and especially metachronous tumors determine the prognosis in this group of patients. Primary tumor multiplicity is not a contraindication both to a radical, including combined, and palliative treatment of each of the tumors.
https://doi.org/10.37469/0507-3758-2012-58-6-754-761
PDF (Русский)

References

Ильин Н. В., Виноградова Ю. Н. Поздние осложнения терапии больных лимфомой Ходжкина // Практ. онкол. 2007, № 8. Р. 96-101.

Скоропад В.Ю., Бердов Б.А. Полинеоплазииу больных ранним раком желудка // Росс. онкол. журнал. — 2008. N 1. С. 10-13.

Состояние онкологической помощи населению Россиив 2010 году. Под. ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2011.

Чиссов В.И., Вашакмадзе Л.А., Бутенко А.В., Морозова П.А. Рак желудка при первично-множественных злокачественных опухолях. В кн.: Первично-множественные злокачественные опухоли. / Под ред. В.И. Чиссова В.И., А.Х. Трахтенберга Х. М., 2000,С. 233-241.

Шахтарина С. В., Даниленко А.А., Павлов В.В. Злокачественные новообразованияу больных лимфомой Ходжкина после лучевой терапии по радикальной программеи комбинированной химиолучевой терапии // Клин. Онкогематол. 2008, № 3, С. 246-252.

AJCC cancer staging handbook. TNM classification of malignant tumors (7th ed.). Springer, 2009.

Dinis-Ribeiro M., Lomba-Viana H., Silva R. et al. Associated primary tumors in patients with gastric cancer // J Clin Gastroenterol. 2002,Vol. 34. P. 533-535.

Dong R.Z., Shi Y.Q., Ye Y.W. et al. Synchronous or metachronous primary cancers of other organs in 74 patients with gastric cancer // Zhonghua Wei Chang Wai Ke Za Zhi. 2010. Vol.13. P. 125-128.

Eom B.W., Lee H.J., Yoo M.W. et al. Synchronous and metachronous cancers in patients with gastric cancer // J Surg Oncol. 2008. Vol. 98. P. 106-110.

Ikeda Y., Saku M., Kawanaka H. et al. Features of second primary cancer in patients with gastric cancer // Oncology. 2003. Vol. 65. P. 13-117.

Ikeguchi M., Ohfuji S., Oka A. et al. Synchronous and metachronous primary malignancies in organs other than the stomach in patients with early gastric cancer // Hepatogastroenterology. 1995, Vol. 42. P. 672-676.

Honda I., Kobayashi D., Fukumoto R. et al. Second malignancy after gastrectomy for early gastric cancer-is there any evidence that adjuvant chemotherapy for early gastric cancer causesa second malignancy? // Gan To Kagaku Ryoho. 2008. Vol. 35(8). P. 1341-1345.

Fitzgerald R.C., Hardwick R., Huntsman D. et al. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research // J Med Genet. 2010,Vol. 47(7). P. 436-444.

Kinoshita Y., Tsukuma H., Ajiki W. The risk for second primaries in gastric cancer patients: adjuvant therapy and habitual smoking and drinking // J Epidemiol. 2000. — Vol. l0. P. 300-304.

Kurishima K., Satoh H., Kagohashi K. et al. Patients with lung cancer with metachronous or synchronous gastric cancer // Clin Lung Cancer. 2009,Vol. 10(6). P. 422-425.

Lee W.S., Lee J.N., Choi S. et al. Multiple primary malignancies Involving colorectal cancer-clinical characteristics and prognosis with reference to surveillance // Langen. becks Arch Surg. 2010,Vol. 395(4). P. 359-64.

Lim J.S., Lee S.K., Hyung W.J. et al. CT colonography for postoperative surveillance after curative gastrectomy in patients with gastric cancer // J Surg Oncol. 2010,Vol. l02. P. 593-598.

Maehara Y., Hasuda S., Koga., Tokunaga E. et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer // Br J Surg. 2000, Vol. 87. P. 353-357.

Molinero A.M., Plaza F.J., Arino T.R. et al. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of Leon // Rev Esp Enferm Dig. 2006. Vol.98. P. 907-916.

Noura S., Ohue M., Seki Y. et al. Second primary cancer in patients with colorectal cancer aftera curative resection // Dig Surg. 2009. Vol. 26(5). P. 400-405.

Takekuni K., Furukawa H., Tsukuma H. The risk of second malignancy after adjuvant chemotherapy for stomach cancer // Gastric Cancer. 1999. Vol. 2. P. 206209.

van den Belt-Dusebout A.W., Aleman B.M., Besseling G. et al. Roles of radiation dose and chemotherapy in the etiology of stomach cancer asa second malignancy // Int J Radiat Oncol Biol Phys. 2009,Vol. 75(5). P. 1420-1429.

Warren S., Gates O. Multiple primary malignant tumors:a survey of the literature anda statistical study. // Am J Cancer. 1932,Vol. 16. P. 1358-1414.

Wu C.W., Lo S.S., Chen J.H. et al. Multiple primary cancers in patients with gastric cancer // Hepatogastroenterology. 2006,Vol. 53. P. 463-467.

Yoon S.N., Oh S.T., Lim S.B. et al. Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer // World J Surg. 2010. Vol. 34,P. 2168-2176.

All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...