PAkt expression in cervical intraepithelial neoplasia and microinvasive cervical cancer
Vol. 58 No. 6 (2012), Articles
Vol. 58 No. 6 (2012)

PAkt expression in cervical intraepithelial neoplasia and microinvasive cervical cancer

Articles
https://doi.org/10.37469/0507-3758-2012-58-6-777-780
Published 15.12.2012
N.N. Blokhin Russian Oncological Scientific Center of the Russian Academy of Medical Sciences
N.N. Blokhin Russian Oncological Scientific Center of the Russian Academy of Medical Sciences
N.N. Blokhin Russian Oncological Scientific Center of the Russian Academy of Medical Sciences
N.N. Blokhin Russian Oncological Scientific Center of the Russian Academy of Medical Sciences
N.N. Blokhin Russian Oncological Scientific Center of the Russian Academy of Medical Sciences
PDF (Русский)

Keywords

CIN
pAkt

How to Cite

, , , , & . (2012). PAkt expression in cervical intraepithelial neoplasia and microinvasive cervical cancer. Voprosy Onkologii, 58(6), 777–780. https://doi.org/10.37469/0507-3758-2012-58-6-777-780
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Abstract

The study objective was an immunohistochemical evaluation of pAkt expression in 81 CIN and microinvasive cervical cancer tissue samples and 10 samples of relatively “normal” cervical epithelium of HPV-infected women. PAkt expression showed significant up-regulation in CIN2, CIN3 and microinvasive cancer in compare to CIN1 and “normal” epithelium. The rate of pAkt- positive cells increased progressively by cervical neoplasia grade advancement reaching 7±5% in CIN2, 15±13% in CIN3 и 17±15% in microinvasive cancer. The rate of pAkt-positive cases in general was 1,7-fold higher in CIN3 (41%) than in CIN2 (24%). pAkt expression in conjunction with other markers may be used in immunohistochemical studies for individual CIN outcome prognosis and prospectively in immunocytochemical tests for CIN grade diagnostics improvement before using invasive methods. To elaborate multicomponent system of markers with their indexation there is a need for further investigations with greater number of cases.
https://doi.org/10.37469/0507-3758-2012-58-6-777-780
PDF (Русский)

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