Clinical and prognostic value of the initial doubling time of prostate-specific antigen in prostate cancer patients
Vol. 58 No. 6 (2012), Articles
Vol. 58 No. 6 (2012)

Clinical and prognostic value of the initial doubling time of prostate-specific antigen in prostate cancer patients

Articles
https://doi.org/10.37469/0507-3758-2012-58-6-817-820
Published 15.12.2012
Russian Research Center for Radiology and Surgical Technologies
Russian Research Center for Radiology and Surgical Technologies
Russian Research Center for Radiology and Surgical Technologies

Abstract

Kinetic parameters of prostate-specific antigen (PSA) play a pivotal role in diagnostic and treatment of patients with prostate cancer (PCr). Assessment of PSA doubling time (PSADT) can be used for monitoring of treatment efficacy and predicting the outcomes of disease. The aim of the present paper is to analyze the PSADT in patients with different spread of PCr. Moreover, the initial PSADTs were studied with relation to overall survival. 336 PCr patients were included into the study. PSADT was measured usng two point method. Ill patients had localized PCr (T1-2N0M0), 90 - regional-local PCr (T1-2N0M0) and 136 had generalized PCr (T1-4N1-2M1). Results: Median PSADT in patients with generalized PCr amounted to 2,93 months and was significantly lower as compared to groups of patients with local and regionallocal spread of disease - 15,2 and 13,2 months respectively. Follow-up results revealed the link between PSADT and survival rates: the lower is PSADT, the worse are survival rates.
https://doi.org/10.37469/0507-3758-2012-58-6-817-820
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