Capsid protein L1 HPV of 16 genotype in a modified cervical epithelium
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Keywords

капсидный белок L1
экспрессия
ВПЧ
дисплазия

How to Cite

, & . (2013). Capsid protein L1 HPV of 16 genotype in a modified cervical epithelium. Voprosy Onkologii, 59(2), 47–51. https://doi.org/10.37469/0507-3758-2013-59-2-47-51

Abstract

The 58 cervical biopsies were studied by cytological, histological, immunomorphological methods, electron microscopy and PCR. Expression of LI was observed only in the differentiated cells of squamous and metaplastic cervical epithelium. At increase of grade of cervical epithelial lesion decrease expression LI from 75 % of cases of CIN1 up to 28,5 % of cases of SCC. Not all capsid structures connect with DNA HPV in case of CIN3.
https://doi.org/10.37469/0507-3758-2013-59-2-47-51
##article.numberofdownloads## 30
##article.numberofviews## 134
PDF (Русский)

References

Apgar B.S., Zoschnick L., Wright J.R. T.C. The 2001 Bethesda system terminology // Amer. Famil. Physic. — 2003. — Vol. 68. — P. 1992-1998.

Doorbar J. The papillomavirus life cycle // J. Clin. Virol. — 2005. — Vol. 32. — Suppl. 1. — S. 7-15.

Griesser H., Sander H., Hilfrich R. A. Correlation of immunochemical detection of HPV L1 capsid protein in Pap smears with regression of high risk positive mild/moderate dysplasia // AQCH. — 2004. — Vol. 26. — P. 241-245.

Griesser H., Sander H., Walczak C., Hilfrich R. A. HPV vaccine protein L1 predicts disease outcome of high-risk HPV+ early squamous dysplastic lesions // Amer. J. Clin. Pathol. — 2009. — Vol. 132. — P. 840-845.

Karageosov I., Dimova R., Makaveeva V. Electron microscopic detection of viruses in cervix papilloma // Zentral-bl. Gynakol. — 1985. — Vol. 107. — P. 187-191.

Kösel S., Burggraf S., Engelhardt W., Olgemöller B. Correlation of HPV16 L1 capsid protein expression in cervical dysplasia with HPV16 DNA concentration, HPV16 E6*I mRNA and histologic outcome // Acta Cytol. — 2009. — Vol. 53. — P. 396-401.

McMurray H.R., Nguyen D., Westbrook T.F., Mcance D.J. Biology of human papillomavirus // Int. J. Pathol. — 2001. — Vol. 82. — P. 13-33.

Multhaupt H.A., Rafferty P.A., Warhol M.J. Ultrastructural localization of human papilloma virus by nonradioactive in situ hybridization on tissue of human cervical intraepithelial neoplasia // Lab. Invest. — 1992. — Vol. 67. — P. 512-518.

Pathology and Genetics of Tumours of the Breast and Female Genital Organs. WHO Classification of Tumours / Eds. F. A. Tavassoli, P. Devilee. — Lyon: IARC Press, 2003. — 432 p.

Sato S., Chiba H., Shikano K. et al. Ultrastructural observation of human papillomavirus particles in the uterine cervix intraepithelial neoplasia // Gan. No Rinsho. — 1988. — Vol. 34. — P. 993-1000.

Stemberger- Papić S., Vrdoljak-Mozetic D., Ostojić D. V. et al. Evaluation of the HPV L1 capsid protein in prognosis of mild and moderate dysplasia of the cervix uteri // Coll. Anthropol. — 2010. — Vol. 34. — P. 419-423.

Ungureanu C., Socolov D., Anton G. et al. Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical lesions progression risk // Roman. J. Morphol. and Embryol. — 2010. — Vol. 51. — P. 497-503.

Wang H.-K., Duffy A.A., Broker T.R. et al. Robust production and passaging of infectious HPV in sguamous epithelium of primary human keratinocytes // Genes Develop. — 2009. — Vol. 23. — P. 181-194.

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