Expression of the transcription factors NF-kB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis
Vol. 70 No. 3 (2024), Articles
Vol. 70 No. 3 (2024)

Expression of the transcription factors NF-kB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis

Articles
https://doi.org/10.37469/0507-3758-2013-59-5-575-579
Published 15.12.2013
Research Institute of Oncology of the Siberian Вranch of the Russian Academy of Medical Sciences
Research Institute of Oncology of the Siberian Вranch of the Russian Academy of Medical Sciences
Research Institute of Oncology of the Siberian Вranch of the Russian Academy of Medical Sciences
Research Institute of Oncology of the Siberian Вranch of the Russian Academy of Medical Sciences
Research Institute of Oncology of the Siberian Вranch of the Russian Academy of Medical Sciences
PDF (Русский)

Keywords

плоскоклеточные карциномы головы и шеи
транскрипционный факторы NF-kB и HIF-1
прогноз заболевания

How to Cite

, , , , & . (2013). Expression of the transcription factors NF-kB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis. Voprosy Onkologii, 70(3), 575–579. https://doi.org/10.37469/0507-3758-2013-59-5-575-579
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Abstract

There was studied an expression of transcription factors NF-kB p65, NF-kB p50 and HIF-1 in the tissue of squamous cell carcinomas of the head and neck. An association of development of regional metastasis of the disease with increased expression of the transcription factor NF-kB p50 was revealed. After treatment there were found relapses within 3 to 47 months in 10 patients, regional lymph node metastases in 3 patients, 12 patients died. Metastasis-free survival of patients with squamous cell carcinomas of the head and neck depended on the threshold level of an expression of the transcription factors NF-kB p65, p50, HIF-1 equal to 9.6, 7.8 and 9 CU/mg protein respectively.
https://doi.org/10.37469/0507-3758-2013-59-5-575-579
PDF (Русский)

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