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The work is based on an analysis of the course of the disease in 185 patients with squamous cell skin cancer. The study program included studies in three major groups. The first included 74 (40%) patients who underwent combined treatment: an operation involving widespread excision of a tumor under intravenous anesthesia + photodynamic therapy (group 1). The second group was 111 (60%) patients with squamous cell carcinoma of the skin who received only operative treatment. To control and compare the obtained laboratory indicators, a second group was created, which included patients without established pathology. This group included 17 people who voluntarily agreed to conduct the study. The study traced the dynamics of changes in hemostasis scores and metalloproteinases in the two groups being compared. In the group of patients with squamous cell skin cancer, there was a statistically significant decrease in the metalloproteinase-1 inhibitor index, which led to an increase in all metalloproteinase-2, -7 and -9 indicators. Performing surgical treatment did not lead to correction of these indicators, both in the near and distant periods after treatment. The mechanism of influence of photodynamic therapy in squamous cell skin cancer can be characterized as follows: there is a decrease in the inhibitor of metalloproteinase-1, which leads to an increase in matrix metalloproteinases-2, -7 and -9 in the blood, as a result of damage to the endothelium of the vascular wall, which is confirmed by an increase in endothelin, this, in turn, led to the development of vasoconstriction and increased procoagulant activity The use of photodynamic therapy restores the index of metalloproteinase-1 inhibitor, this leads to the restoration of matrix metalloproteinases-2, -7 and -9 in the blood and the prevention of damage to the vascular wall. Comprehensive treatment of patients with squamous cell skin cancer in the initial stage of the disease should include photodynamic therapy with simultaneous intravenous blood irradiation, laser tumor training, and then surgical treatment, consisting in excision of the tumor with observance of oncological principles.
References
Состояние онкологической помощи населению России в 2015 году. Под ред. А. Д. Каприна, В. В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИРЦ» Минздрава России, 2016:236 The state of oncological assistance to the population of Russia in 2015. editet by A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoj. M.: P.A. Herzen Moscow Cancer Research Institute - a branch of the Federal State Budgetary Institution "National Medical Research Center for Radiology" of the Ministry of Health, 2016: 236 (In Russ.)].
Хатырев С.А., Погосян А.А., Харатишвили Т.К. Лечение плоскоклеточного рака кожи (обзор литературы). Вестник РОНЦ им. Н.Н. Блохина РАМН. 2003; 14(2-1):69-72 [Hatyrev S.A., Pogosjan A.A., Haratishvili T.K. Treatment of squamous cell skin cancer (literature review). Bulletin Russian Oncology Center named after N.N. Blokhin of the Russian Academy of Medical Sciences. 2003; 14 (2-1): 69-72 (In Russ.)].
Дзыбова Э.М., Варданян К.Л., Василевская Е.А. Плоскоклеточный рак кожи: клиника, диагностика, методы лечения и профилактики. Клиническая дерматология и венерология; 2015(4):4-14 [Dzybova Je.M., Vardanjan K.L., Vasilevskaja E.A. Squamous cell skin cancer: clinic, diagnosis, methods of treatment and prevention. Clinical dermatology and venereology. 2015; 4: 4-14 (In Russ.)].
Матвеева О.В. Результаты фотодинамической терапии базально-клеточного рака кожи с локальным использованием фотосенсибилизатора радахлорин // Радиация и риск (Бюллетень Национального радиационно-эпидемиологического регистра). 2016; 2: 79-90 [Matveeva O.V. Results of photodynamic therapy of basal cell skin cancer with local use of radachlorin photosensitizer. Radiation and risk (Bulletin of the National Radiation and Epidemiological Register). 2016; 2: 79-90 (In Russ.)].
Капинус В.Н., Каплан М.А., Спиченкова И.С. и др. Фотодинамическая терапия эпителиальных злокачественных новообразований кожи. Фотодинамическая терапия и фотодиагностика. 2014; 3(3):9-14 [Kapinus V.N., Kaplan M.A., Spichenkova I.S. et al. Photodynamic therapy of epithelial skin malignancies. Photodynamic therapy and photodiagnostics. 2014; 3 (3): 9-14 (In Russ.)].
Кацалап С.Н., Романко Ю.С. Выбор варианта фотодинамической терапии рецидивной базалиомы. Вестник эстетической медицины. 2012; 11(1):44-48 [Kacalap S.N., Romanko Ju.S. Selection of a photodynamic therapy option for recurrent bazalioma. Bulletin of aesthetic medicine. 2012; 11 (1): 44-48 (In Russ.)].
Каплан М.А., Капинус В.Н., Попучиев В.В. и др. Фотодинамическая терапия: результаты и перспективы. Радиация и риск (Бюллетень Национального радиационно-эпидемиологического регистра). 2013; 22(3):115-123 [Kaplan M.A., Kapinus V.N., Popuchiev V.V. et al. Photodynamic therapy: results and perspectives. Radiation and risk (Bulletin of the National Radiation and Epidemiological Register). 2013; 22 (3): 115-123 (In Russ.)].
Беляев А.М., Прохоров Г.Г., Раджабова З.А., Байкалова О.И. Обзор современных методов лечения плоскоклеточного рака кожи. Вопросы онкологии. 2019; 65(1):7-15 [Belyaev A.M., Prohorov G.G., Radzhabova Z.A., Bajkalova O.I. Review of current treatments for squamous cell skin cancer. Oncology questions. 2019; 65 (1): 7-15 (In Russ.)].
Масляков В.В., Гребнев Д.Ю., Ким Л.М, Дралина О.И., Поляков А.В. Значимость изменений некоторых показателей микроциркуляции у больных базально-клеточным раком кожи в патогенезе развития заболевания. Онкология. Журнал им. П.А. Герцена. 2020; 9(2):42-47. doi.org/10.17116/onkolog2020902142 [Masljakov V.V., Grebnev D.Ju., Kim L.M, Dralina O.I., Poljakov A.V. The significance of changes in some microcirculation indicators in patients with basal cell skin cancer in the pathogenesis of disease development. Oncology. Magazine named after P.A. Herzen. 2020; 9 (2): 42-47. doi.org/10.17116/onkolog2020902142 (In Russ.)].
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