Results of successful treatment of uterine malignant neoplasms in patients with a severe comorbid status (clinical cases)
pdf (Русский)

Keywords

endometrial cancer
comorbidity

How to Cite

Dikareva, E., Говоров, И., Komlichenko, E., Pervunina, T., & Ulrikh, E. (2020). Results of successful treatment of uterine malignant neoplasms in patients with a severe comorbid status (clinical cases). Voprosy Onkologii, 66(6), 659–666. https://doi.org/10.37469/0507-3758-2020-66-6-659-666

Abstract

In Russian Federation, as in other developed countries, endometrial cancer (EC) is the most common malignant tumor within the female reproductive system. Over the past decades, patients with EC more often present with severe comorbidities. They require an individual management approach through the perioperative period in order to prevent possible complications. We performed the analysis of the surgical treatment of 17 patients with endometrial cancer with multiple comorbidities that were treated in Almazov National Medical Research Centre for the period from 01.01.2019 to 30.04.2020. Majority of patients (52.9%)  exceeded 6 points of Charlson index, indicating the presence of 3 or more severe somatic diseases. Due to multidisciplinary treatment approach (including oncologists, cardiologists, cardiac surgeons, intensive care specialists, rheumatologists, and others) radical surgery was performed in all patients.

https://doi.org/10.37469/0507-3758-2020-66-6-659-666
pdf (Русский)

References

Bakkum-Gamez J.N., Gonzalez-Bosquet J., Laack N.N. et al. Current issues in the management of endometrial cancer. Mayo Clin Proc. 2008 Jan;83(1):97-112.

Charlson M.E., Pompei P., Ales K.L. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis 1987; 40(5): 373-383.

Chen L., Liu X., Li M. et al. A novel model to predict cancer-specific survival in patients with early-stage uterine papillary serous carcinoma (UPSC). Cancer Med. 2020 Feb;9(3):988-998.

Colombo N., Creutzberg C., Amant F. et al. ESMO-ESGO- ESTRO Endometrial Consensus Conference Working Group. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol. 2016 Jan;27(1):16-41.

Cusimano M.C., Simpson A.N., Dossa F. et al. Laparoscopic and robotic hysterectomy in endometrial cancer patients with obesity: a systematic review and meta-analysis of conversions and complications. Am J Obstet Gynecol. 2019 Nov;221(5):410-428.

Haggerty J., Fortin M., Beaulieu M.D. et al. At the interface of community and healthcare systems: a longitudinal cohort study on evolving health and the impact of primary healthcare from the patient's perspective. BMC Health Serv Res. 2010 Sep 3;10:258.

Moore K., Brewer M.A. Endometrial Cancer: Is This a New Disease? Am Soc Clin Oncol Educ Book. 2017;37:435-442.

Morice P., Leary A., Creutzberg C. et al. Endometrial cancer. Lancet 2016; 387:1094-108.

Townsend N., Wilson L., Bhatnagar P. et al. Cardiovascular disease in Europe: epidemiological update 2016. European Heart Journal. 2016;37(Issue 42):3232–3245.

Póka R., Baradács I. Comparison of progression-free and overall survival between endometrial cancer patients treated with laparoscopic and open surgical techniques. Orv Hetil. 2020 Mar;161(10):382-388.

Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34.

Truong P.T., Kader H.A., Lacy B. et al. The effects of age and comorbidity on treatment and outcomes in women with endometrial cancer. Am J Clin Oncol. 2005 Apr; 28(2):157-64.

Ward K.K., Shah N.R., Saenz C.C. et al. Cardiovascular disease is the leading cause of death among endometrial cancer patients. Gynecol Oncol. 2012 Aug;126(2):176-9.

Wright J.D., Lewin S.N., Deutsch I. et al. Effect of surgical volume on morbidity and mortality of abdominal hysterectomy for endometrial cancer. Gynecol. 2011 May;117(5):1051-9.

Zhu L., Sun X., Bai W. Nomograms for Predicting Cancer-Specific and Overall Survival Among Patients With Endometrial Carcinoma: A SEER Based Study. Front. Oncol. 10:269.

Бохман Я.В. Рак тела матки. Кишинев: Штиинца, 1972:218 [Bohman YA.V. Rak tela matki. Kishinev: SHtiinca, 1972:218 (In Russ.)].

Бохман Я.В.Руководство по онкогинекологии. Л.:Медицина, 1989:464 [Bohman YA.V.Rukovodstvo po onkoginekologii. L.:Medicina, 1989:464 (In Russ.)].

Всемирная Организация Здравоохранения. Резюме. Всемирный доклад о старении и здоровье. 2015. http://www.who.Int. [Vsemirnaya Organizaciya Zdravoohraneniya. Rezyume. Vsemirnyj doklad o starenii i zdorov'e. 2015g. http://www.who.Int. (In Russ.)].

Мерабишвили В.М. Онкологическая статистика (традиционные методы, новые информационные технологии): Руководство для врачей. Издание второе, дополненное. Часть I., 2015:223 [Merabishvili V.M. Onkologicheskaya statistika (tradicionnye metody, novye informacionnye tekhnologii): Rukovodstvo dlya vrachej. Izdanie vtoroe, dopolnennoe. CHast' I., 2015: 223 (In Russ.)].

Злокачественные новообразования в России в 2018 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019:250 [Zlokachestvennye novoobrazovaniya v Rossii v 2018 godu (zabolevaemost' i smertnost') Pod red. A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoj. M.: MNIOI im. P.A. Gercena filial FGBU «NMIC radiologii» Minzdrava Rossii, 2019:250 ( In Russ.)].

Состояние онкологической помощи населению России в 2018 году. Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019:236 [Sostoyanie onkologicheskoj pomoshchi naseleniyu Rossii v 2018 godu. Pod red. A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoj.M.: MNIOI im. P.A. Gercena filial FGBU «NMIC radiologii» Minzdrava Rossii, 2019. ill. – 236 (In Russ.)].

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