THE STUDY OF ORTHOPEDIA HOMEOBOX GENE EXPRESSION IN DIFFERENT TUMOR AND NORMAL HUMAN TISSUES

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-1-128-134

Published 01.01.2017

Yuliya Karnaukhova⁺⁻
Dmitriy Polev⁺⁻
Larisa Krukovskaya⁺⁻
Andrey Kozlov⁺⁻

Yuliya Karnaukhova

Biomedical center, Peter the Great St. Petersburg State Polytechnic University

Dmitriy Polev

Biomedical center, St. Petersburg State University

Larisa Krukovskaya

Biomedical center, Peter the Great St. Petersburg State Polytechnic University

Andrey Kozlov

Biomedical center, Peter the Great St. Petersburg State Polytechnic University

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Keywords

TUMOR SPECIFIC EXPRESSION
ORTHOPEDIA HOMEOBOX (ОТР)
ORTHOPEDIA HOMEOBOX (OTP)
TUMOR MARKERS
CANCER DIAGNOSTICS

How to Cite

Karnaukhova, Y., Polev, D., Krukovskaya, L., & Kozlov, A. (2017). THE STUDY OF ORTHOPEDIA HOMEOBOX GENE EXPRESSION IN DIFFERENT TUMOR AND NORMAL HUMAN TISSUES. Voprosy Onkologii, 63(1), 128–134. https://doi.org/10.37469/0507-3758-2017-63-1-128-134

Abstract

There was studied the OTP gene expression in different normal and tumor human tissues using PCR with specific primers. OTP gene is expressed in 23 of 29 tumor samples and intron fragment of OTP gene (sequence AI267901) is expressed in 49 of 59 tumor samples of different localization. Studied fragments of OTP gene are not transcribed in normal and embryonic tissues except for normal testis tissue, i.e. they can be classified as cancer-testis transcripts. According to preliminary data AI267901 RNA and OTP gene mRNA are transcribed from different DNA strands. Thus locus of OTP gene provides two independent tumor specific transcripts which are potential markers for the cancer diagnostics.

https://doi.org/10.37469/0507-3758-2017-63-1-128-134

PDF (Русский)

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